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약학대학
약학과
Journal papers
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Extracellular potassium deprivation reversibly dephosphorylates cofilin
Title
Extracellular potassium deprivation reversibly dephosphorylates cofilin
Authors
Jung J.
;
Park H.
;
Kim M.
;
Kim M.-J.
;
Choi E.C.
;
Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림
Issue Date
2006
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291X
Citation
Biochemical and Biophysical Research Communications vol. 345, no. 4, pp. 1393 - 1397
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K+]e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K+]e. Thus, these results suggest that the acute shift of [K+]e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume. © 2006 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2006.05.028
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