Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이화정 | * |
dc.date.accessioned | 2018-05-30T08:13:52Z | - |
dc.date.available | 2018-05-30T08:13:52Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0731-7085 | * |
dc.identifier.other | OAK-3405 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243414 | - |
dc.description.abstract | A column-switching high-performance liquid chromatographic (HPLC) method has been developed and validated for quantification of fluvastatin in rat plasma. Plasma samples were diluted with an equal volume of mobile phase, i.e. acetonitrile-5 mM potassium phosphate buffer (pH 6.8) (15:85, v/v), and the mixture was directly injected onto the HPLC system. The analyte was enriched in a pre-treatment column, while endogenous components were eluted to waste. The analyte was then back-flushed onto an analytical column and quantified with fluorescence detection (λ ex = 305 nm; λ em = 390 nm). The standard curve for the drug was linear in the range 0.5-100 ng mL -1 in rat plasma. The limit of quantitation for plasma was found to be 0.5 ng mL -1. This method has been fully validated and shown to be specific, accurate and precise. The method is simple and rapid because of a minimized sample preparation and appears to be useful for the pharmacokinetic study of fluvastatin. © 2006. | * |
dc.language | English | * |
dc.title | Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 41 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1458 | * |
dc.relation.lastpage | 1462 | * |
dc.relation.journaltitle | Journal of Pharmaceutical and Biomedical Analysis | * |
dc.identifier.doi | 10.1016/j.jpba.2006.03.021 | * |
dc.identifier.wosid | WOS:000238491100059 | * |
dc.identifier.scopusid | 2-s2.0-33646915183 | * |
dc.author.google | Um S.Y. | * |
dc.author.google | Jung S.H. | * |
dc.author.google | Jung S.J. | * |
dc.author.google | Kim J.I. | * |
dc.author.google | Chung S.Y. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Han S.B. | * |
dc.author.google | Choi S.O. | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.date.modifydate | 20240118154655 | * |