NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
자연과학대학
생명과학전공
Journal papers
View : 741 Download: 0
An antioxidant system required for host protection against gut infection in Drosophila
Title
An antioxidant system required for host protection against gut infection in Drosophila
Authors
Ha E.-M.
;
Oh C.-T.
;
Ryu J.-H.
;
Bae Y.-S.
;
Kang S.-W.
;
Jang I.-H.
;
Brey P.T.
;
Lee W.-J.
Ewha Authors
배윤수
;
이원재
;
강상원
SCOPUS Author ID
배윤수
; 이원재
; 강상원
Issue Date
2005
Journal Title
Developmental Cell
ISSN
1534-5807
Citation
Developmental Cell vol. 8, no. 1, pp. 125 - 132
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
A fundamental question that applies to all organisms is how barrier epithelia efficiently manage continuous contact with microorganisms. Here, we show that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract. Strikingly, adult flies with severely reduced IRC expression show high mortality rates even after simple ingestion of microbe-contaminated foods. However, despite the central role that the NF-κB pathway plays in eliciting antimicrobial responses, NF-κB pathway mutant flies are totally resistant to such infections. These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract. Copyright © 2005 by Elsevier Inc.
DOI
10.1016/j.devcel.2004.11.007
Appears in Collections:
자연과학대학
>
생명과학전공
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject