Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2018-05-18T08:15:17Z | - |
dc.date.available | 2018-05-18T08:15:17Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0014-5793 | * |
dc.identifier.other | OAK-2583 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243211 | - |
dc.description.abstract | Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP. In the present study, 3-isobutyl-1-methylxanthine (IBMX) and pentoxifylline, PDE inhibitors, induced osteoclast formation in cocultures of mouse bone marrow cells and calvarial osteoblasts. These inhibitors induced the expression of the osteoclast differentiation factor, TNF-related activation induced cytokine (TRANCE, identical to RANKL, ODF, and OPGL), in calvarial osteoblasts. IBMX induced phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in osteoblasts. Induction of TRANCE expression by IBMX was partially suppressed by the inhibitors of protein kinase A (PKA), ERK, and p38 MAPK, suggesting that activation of ERK and p38 MAPK, as well as PKA, is involved in TRANCE expression by IBMX. Osteoblasts expressed PDE4, a PDE subtype, and rolipram, a selective inhibitor of PDE4, induced TRANCE expression. These results suggest that PDE4 is a key regulator of TRANCE expression in osteoblasts, which in turn controls osteoclast formation. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Phosphodiesterase inhibitors stimulate osteoclast formation via TRANCE/RANKL expression in osteoblasts: Possible involvement of ERK and p38 MAPK pathways | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 579 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 832 | * |
dc.relation.lastpage | 838 | * |
dc.relation.journaltitle | FEBS Letters | * |
dc.identifier.doi | 10.1016/j.febslet.2004.12.066 | * |
dc.identifier.wosid | WOS:000226875400048 | * |
dc.identifier.scopusid | 2-s2.0-12744272433 | * |
dc.author.google | Takami M. | * |
dc.author.google | Cho E.S. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Kamijo R. | * |
dc.author.google | Yim M. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |