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Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway

Title
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway
Authors
Eun J.S.Yim S.-H.Kim E.Kim N.-S.Lee K.-J.
Ewha Authors
이공주
SCOPUS Author ID
이공주scopusscopus
Issue Date
2005
Journal Title
Molecular and Cellular Biology
ISSN
0270-7306JCR Link
Citation
Molecular and Cellular Biology vol. 25, no. 6, pp. 2511 - 2524
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Human Fas-associated factor 1 (hFAF1) is a novel protein having multiubiquitin-related domains. We investigated the cellular functions of hFAF1 and found that valosin-containing protein (VCP), the multiubiquitin chain-targeting factor in the degradation of the ubiquitin-proteasome pathway, is a binding partner of hFAF1. hFAF1 is associated with the ubiquitinated proteins via the newly identified N-terminal UBA domain and with VCP via the C-terminal UBX domain. The overexpression of hFAF1 and a truncated UBA domain inhibited the degradation of ubiquitinated proteins and increased cell death. These results suggest that hFAF1 binding to ubiquitinated protein and VCP is involved in the ubiquitin-proteasome pathway. We hypothesize that hFAF1 may serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
DOI
10.1128/MCB.25.6.2511-2524.2005
Appears in Collections:
약학대학 > 약학과 > Journal papers
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