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자연과학대학
화학·나노과학전공
Journal papers
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Caprolactonic poloxamer analog: PEG-PCL-PEG
Title
Caprolactonic poloxamer analog: PEG-PCL-PEG
Authors
Hwang M.J.
;
Suh J.M.
;
Bae Y.H.
;
Kim S.W.
;
Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문
Issue Date
2005
Journal Title
Biomacromolecules
ISSN
1525-7797
Citation
Biomacromolecules vol. 6, no. 2, pp. 885 - 890
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
The aqueous solution of poly(ethylene glycol)-poly(caprolactone)-pol),(ethylene glycol) (PEG-PCL-PEG) triblock copolymers (>15. wt. %) undergoing "clear sol - gel - turbid sol" transition as the temperature increases from 20 to 60 °C has been developed. Light scattering and 13C NMR study suggested that the transition mechanisms are the micellar aggregation for the clear sol to gel transition (lower transition), whereas the increase in PCL molecular motion for gel to turbid sol transition (upper transition). In contrast to the previous thermogelling biodegradable polymers with a sticky paste morphology, the powder form of the PEG-PCL-PEG triblock copolymers makes it easy to handle and allows fast dissolution in water. Therefore, the lyophilization into a powder form followed by facile reconstitution was possible. This system is believed to be promising for drug delivery, cell therapy, and tissue engineering. © 2005 American Chemical Society.
DOI
10.1021/bm049347a
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