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dc.contributor.author변광호-
dc.date.accessioned2018-05-02T08:15:49Z-
dc.date.available2018-05-02T08:15:49Z-
dc.date.issued2004-
dc.identifier.issn0304-3940-
dc.identifier.otherOAK-2073-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/242818-
dc.description.abstractRepeated injections of nicotine can produce behavioral sensitization, as evidenced by an enhanced locomotor response to a subsequent injection of the drug. Behavioral sensitization has been suggested as a model for studying drug addiction. Acupuncture as a therapeutic intervention is widely used for treatment for many functional disorders, such as substance abuse and mental dysfunction. We examined the effect of acupuncture on nicotine-induced behavioral locomotor activity and c-fos expression in the nucleus accumbens and striatum utilizing the immunocytochemical detection of the Fos protein. The rats were given repeated daily nicotine injections (0.4 mg/kg s.c., twice daily for 7 days) followed by one challenging injection on the 4th day after the last daily injection. Acupuncture at zusanli (ST36), but not control, significantly attenuated expected increase in nicotine-induced locomotor activity and Fos-like-immunoreactivity in the nucleus accumebns and striatum to subsequent nicotine challenge. These findings suggest that acupuncture has a therapeutic effect on nicotine addiction, possibly by modulating postsynaptic neuronal activity in the nucleus accumbens and the striatum. © 2004 Published by Elsevier Ireland Ltd.-
dc.languageEnglish-
dc.titleAcupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume358-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage87-
dc.relation.lastpage90-
dc.relation.journaltitleNeuroscience Letters-
dc.identifier.doi10.1016/j.neulet.2003.12.121-
dc.identifier.wosidWOS:000220328400005-
dc.identifier.scopusid2-s2.0-1542719128-
dc.author.googleChae Y.-
dc.author.googleYang C.H.-
dc.author.googleKwon Y.K.-
dc.author.googleKim M.R.-
dc.author.googlePyun K.-H.-
dc.author.googleHahm D.-H.-
dc.author.googleLee H.-J.-
dc.author.googleShim I.-
dc.date.modifydate20200911081002-
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의과대학 > 의학과 > Journal papers
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