Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 변광호 | - |
dc.date.accessioned | 2018-05-02T08:15:49Z | - |
dc.date.available | 2018-05-02T08:15:49Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.other | OAK-2073 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242818 | - |
dc.description.abstract | Repeated injections of nicotine can produce behavioral sensitization, as evidenced by an enhanced locomotor response to a subsequent injection of the drug. Behavioral sensitization has been suggested as a model for studying drug addiction. Acupuncture as a therapeutic intervention is widely used for treatment for many functional disorders, such as substance abuse and mental dysfunction. We examined the effect of acupuncture on nicotine-induced behavioral locomotor activity and c-fos expression in the nucleus accumbens and striatum utilizing the immunocytochemical detection of the Fos protein. The rats were given repeated daily nicotine injections (0.4 mg/kg s.c., twice daily for 7 days) followed by one challenging injection on the 4th day after the last daily injection. Acupuncture at zusanli (ST36), but not control, significantly attenuated expected increase in nicotine-induced locomotor activity and Fos-like-immunoreactivity in the nucleus accumebns and striatum to subsequent nicotine challenge. These findings suggest that acupuncture has a therapeutic effect on nicotine addiction, possibly by modulating postsynaptic neuronal activity in the nucleus accumbens and the striatum. © 2004 Published by Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 358 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 87 | - |
dc.relation.lastpage | 90 | - |
dc.relation.journaltitle | Neuroscience Letters | - |
dc.identifier.doi | 10.1016/j.neulet.2003.12.121 | - |
dc.identifier.wosid | WOS:000220328400005 | - |
dc.identifier.scopusid | 2-s2.0-1542719128 | - |
dc.author.google | Chae Y. | - |
dc.author.google | Yang C.H. | - |
dc.author.google | Kwon Y.K. | - |
dc.author.google | Kim M.R. | - |
dc.author.google | Pyun K.-H. | - |
dc.author.google | Hahm D.-H. | - |
dc.author.google | Lee H.-J. | - |
dc.author.google | Shim I. | - |
dc.date.modifydate | 20200911081002 | - |