Synthesis of novel thiol surrogate of Taxol®: 2′-deoxy-2′- mercaptopaclitaxel

Abstract

Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side chain constitute an interesting avenue of research for the study of new taxoid compounds. A synthetic route for the preparation of the exact thiol surrogate product of Taxol ® by coupling (4S, 5S)-2,4-diphenyloxazoline-5-carboxylic acid with 7-triethylsilyl baccatin III, followed by ring-opening of the oxazoline intermediate with thiolacetic acid is described. © 2004 Elsevier Ltd. All rights reserved.