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Synthesis of novel thiol taxoids based on the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III: Both the syn and anti 10-deacetyl-2′-deoxy-2′-mercaptopaclitaxels
- Title
- Synthesis of novel thiol taxoids based on the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III: Both the syn and anti 10-deacetyl-2′-deoxy-2′-mercaptopaclitaxels
- Authors
- Qi X.; Lee S.-H.; Yoon J.; Lee Y.-S.
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2004
- Journal Title
- Tetrahedron
- ISSN
- 0040-4020
- Citation
- Tetrahedron vol. 60, no. 19, pp. 4133 - 4138
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Two new kinds of docetaxel compound, with a mercapto group instead of the hydroxyl on the C13 side chain (both syn and anti), via the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III route, were synthesized. The uses of trans and cis oxazoline compounds, and their stereoselective ring-opening reactions with thiolacetic acid, were proved to be key steps. © 2004 Elsevier Ltd. All rights reserved.
- DOI
- 10.1016/j.tet.2004.03.064
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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