Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전길자 | - |
dc.contributor.author | 한소엽 | - |
dc.date.accessioned | 2018-05-02T08:15:33Z | - |
dc.date.available | 2018-05-02T08:15:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.other | OAK-2246 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242737 | - |
dc.description.abstract | Monoacetyldiglycerides purified from deer antler, and identical synthetic compounds, have been shown to stimulate hematopoiesis. In the present study, we synthesized eight monoacetyldiglycerides, one of which, 1-palmitoyl-2-linoleoyl- 3-acetyl-rac-glycerol (3), was structurally identical to one of the naturally occurring monoacetyldiglycerides and showed the most potent stimulation of hematopoiesis by colony forming unit in culture (CFUc) assay, having a stimulation index (SI) of 1.54±0.23 at a concentration of 1.0 μg/ml. Moreover, 1.0 μg/ml 3 showed potent growth-stimulation activities on megakaryocyte culture, long term culture of Lin -Sca-1 + cells with irradiated MS-5 stromal cells (SI, 1.69±0.16), and on the number of cobblestone colonies (SI, 10.4±0.25). In a murine model, 3, at concentrations of 0.5, 5 and 50 mg/kg/d, i.p. and p.o., effectively stimulated hematopoiesis in vivo 7 d after syngenic bone marrow transplantation of irradiated C57BL/6 mice, when assayed by the colony forming units in spleen (CFUs) assay. These data suggest that monoacetyldiglycerides may have significant clinical potential for the acceleration of hematopoiesis. © 2004 Pharmaceutical Society of Japan. | - |
dc.language | English | - |
dc.title | Stimulatory effects of monoacetyldiglycerides on hematopoiesis | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 27 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1121 | - |
dc.relation.lastpage | 1125 | - |
dc.relation.journaltitle | Biological and Pharmaceutical Bulletin | - |
dc.identifier.doi | 10.1248/bpb.27.1121 | - |
dc.identifier.wosid | WOS:000222421000035 | - |
dc.identifier.scopusid | 2-s2.0-16644383148 | - |
dc.author.google | Yang H.O. | - |
dc.author.google | Park J.-S. | - |
dc.author.google | Cho S.-H. | - |
dc.author.google | Yoon J.-Y. | - |
dc.author.google | Kim M.-G. | - |
dc.author.google | Jhon G.-J. | - |
dc.author.google | Han S.-Y. | - |
dc.author.google | Kim S.H. | - |
dc.contributor.scopusid | 전길자(6701488476) | - |
dc.contributor.scopusid | 한소엽(7405944194) | - |
dc.date.modifydate | 20200928112844 | - |