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dc.contributor.author전길자-
dc.contributor.author한소엽-
dc.date.accessioned2018-05-02T08:15:33Z-
dc.date.available2018-05-02T08:15:33Z-
dc.date.issued2004-
dc.identifier.issn0918-6158-
dc.identifier.otherOAK-2246-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/242737-
dc.description.abstractMonoacetyldiglycerides purified from deer antler, and identical synthetic compounds, have been shown to stimulate hematopoiesis. In the present study, we synthesized eight monoacetyldiglycerides, one of which, 1-palmitoyl-2-linoleoyl- 3-acetyl-rac-glycerol (3), was structurally identical to one of the naturally occurring monoacetyldiglycerides and showed the most potent stimulation of hematopoiesis by colony forming unit in culture (CFUc) assay, having a stimulation index (SI) of 1.54±0.23 at a concentration of 1.0 μg/ml. Moreover, 1.0 μg/ml 3 showed potent growth-stimulation activities on megakaryocyte culture, long term culture of Lin -Sca-1 + cells with irradiated MS-5 stromal cells (SI, 1.69±0.16), and on the number of cobblestone colonies (SI, 10.4±0.25). In a murine model, 3, at concentrations of 0.5, 5 and 50 mg/kg/d, i.p. and p.o., effectively stimulated hematopoiesis in vivo 7 d after syngenic bone marrow transplantation of irradiated C57BL/6 mice, when assayed by the colony forming units in spleen (CFUs) assay. These data suggest that monoacetyldiglycerides may have significant clinical potential for the acceleration of hematopoiesis. © 2004 Pharmaceutical Society of Japan.-
dc.languageEnglish-
dc.titleStimulatory effects of monoacetyldiglycerides on hematopoiesis-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume27-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1121-
dc.relation.lastpage1125-
dc.relation.journaltitleBiological and Pharmaceutical Bulletin-
dc.identifier.doi10.1248/bpb.27.1121-
dc.identifier.wosidWOS:000222421000035-
dc.identifier.scopusid2-s2.0-16644383148-
dc.author.googleYang H.O.-
dc.author.googlePark J.-S.-
dc.author.googleCho S.-H.-
dc.author.googleYoon J.-Y.-
dc.author.googleKim M.-G.-
dc.author.googleJhon G.-J.-
dc.author.googleHan S.-Y.-
dc.author.googleKim S.H.-
dc.contributor.scopusid전길자(6701488476)-
dc.contributor.scopusid한소엽(7405944194)-
dc.date.modifydate20200928112844-


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