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Stimulatory effects of monoacetyldiglycerides on hematopoiesis

Title
Stimulatory effects of monoacetyldiglycerides on hematopoiesis
Authors
Yang H.O.Park J.-S.Cho S.-H.Yoon J.-Y.Kim M.-G.Jhon G.-J.Han S.-Y.Kim S.H.
Ewha Authors
전길자한소엽
SCOPUS Author ID
전길자scopus; 한소엽scopus
Issue Date
2004
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
Biological and Pharmaceutical Bulletin vol. 27, no. 7, pp. 1121 - 1125
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Monoacetyldiglycerides purified from deer antler, and identical synthetic compounds, have been shown to stimulate hematopoiesis. In the present study, we synthesized eight monoacetyldiglycerides, one of which, 1-palmitoyl-2-linoleoyl- 3-acetyl-rac-glycerol (3), was structurally identical to one of the naturally occurring monoacetyldiglycerides and showed the most potent stimulation of hematopoiesis by colony forming unit in culture (CFUc) assay, having a stimulation index (SI) of 1.54±0.23 at a concentration of 1.0 μg/ml. Moreover, 1.0 μg/ml 3 showed potent growth-stimulation activities on megakaryocyte culture, long term culture of Lin -Sca-1 + cells with irradiated MS-5 stromal cells (SI, 1.69±0.16), and on the number of cobblestone colonies (SI, 10.4±0.25). In a murine model, 3, at concentrations of 0.5, 5 and 50 mg/kg/d, i.p. and p.o., effectively stimulated hematopoiesis in vivo 7 d after syngenic bone marrow transplantation of irradiated C57BL/6 mice, when assayed by the colony forming units in spleen (CFUs) assay. These data suggest that monoacetyldiglycerides may have significant clinical potential for the acceleration of hematopoiesis. © 2004 Pharmaceutical Society of Japan.
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DOI
10.1248/bpb.27.1121
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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