Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | * |
dc.contributor.author | 강상원 | * |
dc.contributor.author | 창동신 | * |
dc.date.accessioned | 2018-05-02T08:15:26Z | - |
dc.date.available | 2018-05-02T08:15:26Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0021-9258 | * |
dc.identifier.other | OAK-2360 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242689 | - |
dc.description.abstract | Various proapoptotic stimuli increase the production of superoxide and H 2O 2 by mitochondria. Whereas superoxide impairs mitochondrial function and is removed by Mn 2+-dependent superoxide dismutase, the role and metabolism of mitochondrial H 2O 2 during apoptosis have remained unclear. The effects on apoptotic signaling of depletion of peroxiredoxin (Prx) III, a mitochondrion-specific H 2O 2-scavenging enzyme, have now been investigated by RNA interference in HeLa cells. Depletion of Prx III resulted in increased intracellular levels of H 2O 2 and sensitized cells to induction of apoptosis by staurosporine or TNF-α. The rates of mitochondrial membrane potential collapse, cytochrome c release, and caspase activation were increased in Prx III-depleted cells, and these effects were reversed by ectopic expression of Prx III or mitochondrion-targeted catalase. Depletion of Prx III also exacerbated damage to mitochondrial macromolecules induced by the proapoptotic stimuli. Our results suggest that Prx III is a critical regulator of the abundance of mitochondrial H 2O 2, which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling. | * |
dc.language | English | * |
dc.title | Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria | * |
dc.type | Article | * |
dc.relation.issue | 40 | * |
dc.relation.volume | 279 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 41975 | * |
dc.relation.lastpage | 41984 | * |
dc.relation.journaltitle | Journal of Biological Chemistry | * |
dc.identifier.doi | 10.1074/jbc.M407707200 | * |
dc.identifier.wosid | WOS:000224075500090 | * |
dc.identifier.scopusid | 2-s2.0-4744373181 | * |
dc.author.google | Chang T.-S. | * |
dc.author.google | Cho C.-S. | * |
dc.author.google | Park S. | * |
dc.author.google | Yu S. | * |
dc.author.google | Sang W.K. | * |
dc.author.google | Sue G.R. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 창동신(7404726037) | * |
dc.date.modifydate | 20240423081003 | * |