Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최선 | * |
dc.contributor.author | 차선신 | * |
dc.date.accessioned | 2018-04-25T08:13:39Z | - |
dc.date.available | 2018-04-25T08:13:39Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0141-8130 | * |
dc.identifier.issn | 1879-0003 | * |
dc.identifier.other | OAK-21873 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242573 | - |
dc.description.abstract | The DJ-1 protein engages in diverse cellular and pathological processes, including tumorigenesis, apoptosis, sperm fertilization, and the progression of Parkinson's disease (PD). The functional dimeric form of DJ-1 transforms into non-functional filamentous aggregates in an inorganic phosphate (P-1)-dependent manner in vitro. Here, we demonstrated that P-i and reactive oxygen species (ROS) induce DJ-1 aggregation in Neuro2A and SH-SY5Y cells. Remarkably, tartrate treatment significantly reduced P-i- and ROS-induced DJ-1 aggregation and restored P-i- and ROS-provoked cell death using quantitative data as mean +/- standard deviation, and statistics. Mechanistically, tartrate prevented DJ-1 aggregation via occupying the P-i-binding site. These findings revealed an unexpected physiological role of tartrate in the maintenance of DJ-1 function, and thus, a potential use as an inhibitor of DJ-1 aggregation. (C) 2017 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Tartrate | * |
dc.subject | DJ-1 | * |
dc.subject | Parkinson's disease | * |
dc.subject | Inorganic phosphate | * |
dc.subject | ROS | * |
dc.title | Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation | * |
dc.type | Article | * |
dc.relation.volume | 107 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1650 | * |
dc.relation.lastpage | 1658 | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | * |
dc.identifier.doi | 10.1016/j.ijbiomac.2017.10.022 | * |
dc.identifier.wosid | WOS:000424062300032 | * |
dc.identifier.scopusid | 2-s2.0-85031501683 | * |
dc.author.google | Kim, Min Soo | * |
dc.author.google | Lee, Sangmin | * |
dc.author.google | Yun, Sanguk | * |
dc.author.google | Suh, Pann-Ghill | * |
dc.author.google | Park, Jongmi | * |
dc.author.google | Cui, Minghua | * |
dc.author.google | Choi, Sun | * |
dc.author.google | Cha, Sun-Shin | * |
dc.author.google | Jin, Wook | * |
dc.contributor.scopusid | 최선(8659831000) | * |
dc.contributor.scopusid | 차선신(7201864593) | * |
dc.date.modifydate | 20240305081003 | * |