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Injectable thermogel for 3D culture of stem cells
- Title
- Injectable thermogel for 3D culture of stem cells
- Authors
- Patel, Madhumita; Lee, Hyun Jung; Park, Sohee; Kim, Yelin; Jeong, Byeongmoon
- Ewha Authors
- 정병문
- SCOPUS Author ID
- 정병문
- Issue Date
- 2018
- Journal Title
- BIOMATERIALS
- ISSN
- 0142-9612
1878-5905
- Citation
- BIOMATERIALS vol. 159, pp. 91 - 107
- Keywords
- Thermogel; Stem cell; 3D culture; Tissue engineering; Temperature-sensitivity
- Publisher
- ELSEVIER SCI LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Thermogel is an aqueous polymer solution that undergoes sol-to-gel transition as the temperature increases. Cells, growth factors, and signaling molecules can be incorporated simultaneously during the sol-to-gel transition. The cytocompatible procedure makes the thermogel an excellent platform for 3D culture of stem cells. This review focuses on the crucial questions that need to be addressed to achieve effective differentiation of stem cells into target cells, comprising low modulus, cell adhesion, and controlled supply of the growth factors. Recent progress in the use of thermogel as a 3D culture system of stem cells is summarized, and our perspectives on designing a new thermogel for 3D culture and its eventual application to injectable tissue engineering of stem cells are presented. (C) 2018 Elsevier Ltd. All rights reserved.
- DOI
- 10.1016/j.biomaterials.2018.01.001
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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