Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2018-04-25T08:13:30Z | - |
dc.date.available | 2018-04-25T08:13:30Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.issn | 1464-3405 | * |
dc.identifier.other | OAK-22081 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242517 | - |
dc.description.abstract | Human DNA topoisomerases have become attractive targets for developing more effective anticancer drugs. In this study, a series of new benzofuro[3,2-b] pyridin-7-ols were designed and synthesized for the first time and screened for their topoisomerase I and II inhibitory and antiproliferative activity. Structure-activity relationships revealed the position of ortho-and para-hydroxyl group at 2-phenyl ring, and meta-hydroxyl group at 4-phenyl ring of benzofuro[3,2-b] pyridin-7-ol are important for potent and selective topo II inhibitory activity. Compound 11 showed the most selective and potent topo II inhibition (100% inhibition at 100 mM) and strongest antiproliferative activity (IC50 = 0.86 mu M) than all the positive controls in HeLa cell line. (C) 2018 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Fused heterocycles | * |
dc.subject | Benzofuro[3,2-b]pyridin-7-ol | * |
dc.subject | Hydroxyl-substituent | * |
dc.subject | Topoisomerase inhibition | * |
dc.subject | Antiproliferative activity | * |
dc.subject | Structure-activity relationship | * |
dc.title | Design, synthesis, and structure-activity relationships of new benzofuro [3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 28 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 566 | * |
dc.relation.lastpage | 571 | * |
dc.relation.journaltitle | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | * |
dc.identifier.doi | 10.1016/j.bmcl.2018.01.048 | * |
dc.identifier.wosid | WOS:000425882800005 | * |
dc.identifier.scopusid | 2-s2.0-85041339061 | * |
dc.author.google | Shrestha, Aarajana | * |
dc.author.google | Jo, Hyunji | * |
dc.author.google | Kwon, Youngjoo | * |
dc.author.google | Lee, Eung-Seok | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |