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Current medical treatment of uterine fibroids

Title
Current medical treatment of uterine fibroids
Authors
Sohn G.S.Cho S.Kim Y.M.Cho C.-H.Kim M.R.Lee S.R.
Ewha Authors
이사라
SCOPUS Author ID
이사라scopus
Issue Date
2018
Journal Title
Obstetrics and Gynecology Science
ISSN
2287-8572JCR Link
Citation
Obstetrics and Gynecology Science vol. 61, no. 2, pp. 192 - 201
Keywords
GnRH receptorUterine fibroids
Publisher
Korean Society of Obstetrics and Gynecology
Indexed
SCOPUS; KCI scopus
Document Type
Review
Abstract
Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common benign tumors in women. Heavy or prolonged menstrual bleeding, abnormal uterine bleeding, resultant anemia, pelvic pain, infertility, and/or recurrent pregnancy loss are generally associated with uterine fibroids. Although curative treatment of this tumor relies on surgical therapies, medical treatments are considered the first-line treatment to preserve fertility and avoid or delay surgery. The aim of this review is to provide available and emerging medical treatment options for symptomatic uterine fibroids. Literature review and consensus of expert opinion. Many uterine fibroids are asymptomatic and require no intervention, although it is advisable to follow-up patients to document stability in size and growth. Fibroid-associated symptoms include heavy menstrual bleeding and pain or pelvic discomfort. The association between infertility and fibroids increases with age. Treatment options for symptomatic uterine fibroids -include medical, surgical, and radiologically guided interventions. Various medical therapies are now available for women with uterine fibroids, although each therapy has its own advantages and disadvantages. Currently, gonadotrophin-releasing hormone (GnRH) agonists and selective progesterone receptor modulators (SPRMs) are the most effective medical therapies, with the most evidence to support their reduction of fibroid volume and symptomatic improvement in menstrual bleeding. The choice of treatment depends on the patient's personal treatment goals, as well as efficacy and need for repeated interventions. ©2018 Korean Society of Obstetrics and Gynecology.
DOI
10.5468/ogs.2018.61.2.192
Appears in Collections:
의과대학 > 의학과 > Journal papers
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