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Monoamine Oxidase (MAO) Inhibitors from Marine-derived actinomycetes Streptomyces sp. CNQ027

Title
Monoamine Oxidase (MAO) Inhibitors from Marine-derived actinomycetes Streptomyces sp. CNQ027
Authors
최한솔
Issue Date
2018
Department/Major
대학원 화학·나노과학과
Publisher
이화여자대학교 대학원
Degree
Master
Advisors
남상집
Abstract
Marine derived microorganisms are remarkable sources of natural products discovery and are abundant sources of unknown and bioactive compounds. Marine organisms are living in the diverse environments. These can constitute a very important source of new medical agents such as anti-cancer, anti-inflammatory, analgesic etc. Monoamine oxidase inhibitors (MAOIs) use as medications for the depression, Parkinson’s disease, and other related disorders. Two compounds isolated from marine derived Streptomyces sp. CNQ-027 were tested for the monoamine oxidase (MAO) inhibitory activities of two MAO isoforms, which catalyzes monoamine neurotransmitters. In this study, two piloquinone derivatives showed inhibition against MAO-A and –B. These results propose that piloquinones should be potent reversible MAOIs and useful MAO enzyme inhibitors to treat connected disorders. The structures of two compounds were presented by LC/MS, 1H-NMR and literature data.;해양 유래 미생물은 천연물 개발의 잠재적인 원료이며 새로운 물질과 생리 활성의 풍부한 자원으로 여겨지고 있다. 다양한 환경에서 서식하는 해양 생물은 항암, 항염, 항알러지 등의 신약 개발에 있어 매우 중요한 기반이 됨을 의미한다. 모노아민산화효소억제제 (Monoamine oxidase inhibitor, MAOI)는 우울증, 파킨슨병, 이와 관련된 질병의 치료제로 사용된다. 본 연구에서는 해양에서 유래된 Streptomyces sp. CNQ-027로부터 두 가지의 piloquinone 유도체 4,7-dihydroxy-3-methyl-2-(4-methyl-1-oxopentyl)- 6H-dibenzo[b,d]pyran-6-one (1)과 1,8-dihydroxy-2-methyl-3-(4-methyl-1-oxopentyl)-9,10-phenanthrenedione (2)를 분리하였다. 이 두 가지 물질에 대해 MAO 저해 활성 실험을 진행한 결과 1번 물질이 MAO-B에 대해 높은 저해 활성을 나타내었고 이는 물질 1이 우울증, 파킨슨병의 치료제로서 가능성을 보여준다.
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