Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2018-02-27T16:30:22Z | - |
dc.date.available | 2018-02-27T16:30:22Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1936-0851 | * |
dc.identifier.other | OAK-22004 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239972 | - |
dc.description.abstract | Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy. © 2017 American Chemical Society. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | activatable | * |
dc.subject | nanotheranostics | * |
dc.subject | nucleic-acid-responsive disassembly | * |
dc.subject | photodynamic therapy | * |
dc.subject | supramolecular assembly | * |
dc.title | Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 681 | * |
dc.relation.lastpage | 688 | * |
dc.relation.journaltitle | ACS Nano | * |
dc.identifier.doi | 10.1021/acsnano.7b07809 | * |
dc.identifier.wosid | WOS:000423495200073 | * |
dc.identifier.scopusid | 2-s2.0-85042199129 | * |
dc.author.google | Li X. | * |
dc.author.google | Yu S. | * |
dc.author.google | Lee D. | * |
dc.author.google | Kim G. | * |
dc.author.google | Lee B. | * |
dc.author.google | Cho Y. | * |
dc.author.google | Zheng B.-Y. | * |
dc.author.google | Ke M.-R. | * |
dc.author.google | Huang J.-D. | * |
dc.author.google | Nam K.T. | * |
dc.author.google | Chen X. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |