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dc.contributor.author홍영미-
dc.contributor.author조민선-
dc.contributor.author김관창-
dc.date.accessioned2017-12-28T16:30:20Z-
dc.date.available2017-12-28T16:30:20Z-
dc.date.issued2017-
dc.identifier.issn1738-1061-
dc.identifier.otherOAK-21765-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/239522-
dc.description.abstractPurpose: The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role in ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were separated into 2 groups: the control group (C group) and the experimental group (ADR 5 mg/wk for 3 weeks through intraperitoneal injections; A group). Echocardiographic images were obtained at week 3. Changes in caspase-3, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), interleukin (IL)-6, tumor necrosis factor-α, brain natriuretic peptide (BNP), troponin I, collagen 1, and collagen 3 protein expression from the left ventricle tissues of C and A group rats were determined by Western blot. Results: Ascites and heart failure as well as left ventricular hypertrophy were noted in the A group. Ejection fraction and shortening fraction were significantly lower in the A group by echocardiography. The expression of caspase-3, Bax, IL-6, BNP, collagen 1, and collagen 3 were significantly higher in the A group as compared with the C group. Protein expression of Bcl-2 decreased significantly in the A group compared with the C group. Conclusion: ADR induced an upregulation of caspase-3, Bax, IL-6, and collagen, as well as a depression in Bcl-2. Thus, apoptosis and fibrosis may play an important role in ADR-induced cardiomyopathy. © 2017 by The Korean Pediatric Society.-
dc.languageEnglish-
dc.publisherKorean Pediatric Society-
dc.subjectApoptosis-
dc.subjectCardiomyopathies-
dc.subjectDoxorubicin-
dc.subjectVentricular remodeling-
dc.titleApoptosis and remodeling in adriamycin-induced cardiomyopathy rat model-
dc.typeArticle-
dc.relation.issue11-
dc.relation.volume60-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage365-
dc.relation.lastpage372-
dc.relation.journaltitleKorean Journal of Pediatrics-
dc.identifier.doi10.3345/kjp.2017.60.11.365-
dc.identifier.scopusid2-s2.0-85035003483-
dc.author.googleHong Y.M.-
dc.author.googleLee H.-
dc.author.googleCho M.-S.-
dc.author.googleKim K.C.-
dc.contributor.scopusid홍영미(35210025100)-
dc.contributor.scopusid조민선(13205279200)-
dc.contributor.scopusid김관창(36652690000)-
dc.date.modifydate20210915163347-
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의과대학 > 의학과 > Journal papers
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