Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.date.accessioned | 2017-12-27T16:30:43Z | - |
dc.date.available | 2017-12-27T16:30:43Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1672-7681 | * |
dc.identifier.other | OAK-21535 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239353 | - |
dc.description.abstract | Effector B cells are central contributors to the development of autoimmune disease by activating autoreactive T cells, producing pro-inflammatory cytokines and organizing ectopic lymphoid tissue. Conversely, IL-10-producing regulatory B (Breg) cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory disease. Thus, regulating the equilibrium between antibody-producing effector B cells and Breg cells is critical for the treatment of autoimmune disease. In this study, we investigated the effect of human palatine tonsil-derived mesenchymal stem cells (T-MSCs) on estradiol (E2)-induced B-cell responses in vivo and in vitro. Transplantation of T-MSC into E2-treated mice alleviated B-cell-mediated immune responses and increased the population of IL-10-producing Breg cells. T-MSCs regulated the B-cell populations by producing Epstein-Barr virus (EBV)-induced 3 (EBI3), one of the two subunits of IL-35 that is the well-known inducer of Breg cells. We demonstrate a critical role of EBI3 (IL-35) in vitro by depleting EBI3 in T-MSCs and by adding exogenous IL-35 to the culture system. Taken together, our data suggest that IL-35-secreting MSCs may become an attractive therapeutic to treat B-cell-mediated autoimmune diseases via expanding Breg cells. © 2017 CSI and USTC. All rights reserved. | * |
dc.language | English | * |
dc.publisher | Chinese Soc Immunology | * |
dc.subject | autoimmune disease | * |
dc.subject | B cells | * |
dc.subject | IL-35 | * |
dc.subject | mesenchymal stem cells | * |
dc.title | Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 895 | * |
dc.relation.lastpage | 908 | * |
dc.relation.journaltitle | Cellular and Molecular Immunology | * |
dc.identifier.doi | 10.1038/cmi.2016.59 | * |
dc.identifier.wosid | WOS:000414427000007 | * |
dc.identifier.scopusid | 2-s2.0-85030085682 | * |
dc.author.google | Cho K.-A. | * |
dc.author.google | Lee J.-K. | * |
dc.author.google | Kim Y.-H. | * |
dc.author.google | Park M. | * |
dc.author.google | Woo S.-Y. | * |
dc.author.google | Ryu K.-H. | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.date.modifydate | 20240118130224 | * |