Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하헌주 | * |
dc.date.accessioned | 2017-11-01T05:01:56Z | - |
dc.date.available | 2017-11-01T05:01:56Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0041-008X | * |
dc.identifier.other | OAK-21141 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239060 | - |
dc.description.abstract | Although favorable immune responses to low-dose irradiation (LDI) have been observed in normal mice, i.e., a hormesis effect, little is known about the effects of LDI in infectious diseases. In this study, we examined the effects of LDI on mice with sepsis, a severe and often lethal hyperinflammatory response to bacteria. Female C57BL/6 mice were whole-body irradiated with 10 cGy 48 h before Escherichia coli infection, and survival, bacterial clearance, cytokines, and antioxidants were quantified. LDI pretreatment significantly increased survival from 46.7% in control mice to 75% in mice with sepsis. The bacterial burden was significantly lower in the blood, spleen, and kidney of LDI-treated mice than in those of control septic mice. The levels of pro-inflammatory cytokines, e.g., IL-1β and IL-6, as well as anti-inflammatory IL-10 were markedly reduced in pre-LDI septic mice. Nitric oxide production by peritoneal macrophages was also reduced in pre-LDI septic mice. Immune cells in the spleen increased and Nrf2 and HO-1 were induced in pre-LDI septic mice. LDI stimulates the immune response and minimizes lethality in septic mice via enhanced bacterial clearance and reduced initial proinflammatory responses. © 2017 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Academic Press Inc. | * |
dc.subject | Antioxidant | * |
dc.subject | Immune response | * |
dc.subject | Inflammation | * |
dc.subject | Low-dose irradiation | * |
dc.subject | Sepsis | * |
dc.title | Effects of low-dose irradiation on mice with Escherichia coli-induced sepsis | * |
dc.type | Article | * |
dc.relation.volume | 333 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 17 | * |
dc.relation.lastpage | 25 | * |
dc.relation.journaltitle | Toxicology and Applied Pharmacology | * |
dc.identifier.doi | 10.1016/j.taap.2017.08.008 | * |
dc.identifier.wosid | WOS:000411549600003 | * |
dc.identifier.scopusid | 2-s2.0-85027409059 | * |
dc.author.google | Song K.-H. | * |
dc.author.google | Jung S.-Y. | * |
dc.author.google | Kho S.-H. | * |
dc.author.google | Hwang S.-G. | * |
dc.author.google | Ha H. | * |
dc.author.google | Nam S.Y. | * |
dc.author.google | Song J.-Y. | * |
dc.contributor.scopusid | 하헌주(7202277106) | * |
dc.date.modifydate | 20240422113229 | * |