Highly Efficient One-Pot Solvent-Free Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole via BTI-mediated Oxidation of N-Acylhydrazone from Hydrazide and Aldehyde

Abstract

2,5-Disubstituted-1,3,4-oxadiazoles are prepared in excellent yields ( up to 97%) under totally solvent-free conditions by the quantitative formation of N-acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball-mill for 10 min at room temperature followed by oxidation with BTI at 80 degrees C for 1h.