Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영선 | * |
dc.contributor.author | 류인균 | * |
dc.contributor.author | 윤수정 | * |
dc.contributor.author | 김정윤 | * |
dc.date.accessioned | 2017-08-25T05:08:04Z | - |
dc.date.available | 2017-08-25T05:08:04Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0012-186X | * |
dc.identifier.other | OAK-20854 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235692 | - |
dc.description.abstract | Aims/hypothesis: Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. Methods: This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. Results: Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = −2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = −2.12, p for interaction = 0.03), while normal-weight participants did not. Conclusions/interpretation: The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants. © 2017, Springer-Verlag Berlin Heidelberg. | * |
dc.language | English | * |
dc.publisher | Springer Verlag | * |
dc.subject | Cognitive function | * |
dc.subject | Grey matter | * |
dc.subject | Obesity | * |
dc.subject | Overweight | * |
dc.subject | Type 2 diabetes mellitus | * |
dc.subject | White matter | * |
dc.title | Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 60 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1207 | * |
dc.relation.lastpage | 1217 | * |
dc.relation.journaltitle | Diabetologia | * |
dc.identifier.doi | 10.1007/s00125-017-4266-7 | * |
dc.identifier.wosid | WOS:000402553400007 | * |
dc.identifier.scopusid | 2-s2.0-85018307649 | * |
dc.author.google | Yoon S. | * |
dc.author.google | Cho H. | * |
dc.author.google | Kim J. | * |
dc.author.google | Lee D.-W. | * |
dc.author.google | Kim G.H. | * |
dc.author.google | Hong Y.S. | * |
dc.author.google | Moon S. | * |
dc.author.google | Park S. | * |
dc.author.google | Lee S. | * |
dc.author.google | Bae S. | * |
dc.author.google | Simonson D.C. | * |
dc.author.google | Lyoo I.K. | * |
dc.contributor.scopusid | 홍영선(7403393456) | * |
dc.contributor.scopusid | 류인균(55664289900) | * |
dc.contributor.scopusid | 윤수정(15766754400) | * |
dc.contributor.scopusid | 김정윤(56993024200) | * |
dc.date.modifydate | 20240301081003 | * |