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dc.contributor.author김양하-
dc.contributor.author장유진-
dc.date.accessioned2017-04-25T01:04:27Z-
dc.date.available2017-04-25T01:04:27Z-
dc.date.issued2017-
dc.identifier.issn2072-6643-
dc.identifier.otherOAK-20430-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/235009-
dc.description.abstractObesity is recognized as a state of chronic low-grade systemic inflammation due to adipose tissue macrophage infiltration and production of proinflammatory adipokines. Decreased vitamin D status is associated with obesity. The specific aim of the present study is to investigate the effects of vitamin D on obesity-induced adipose tissue inflammation. Male Sprague-Dawley rats were randomized and fed a normal diet (NOR, 1000 IU vitamin D/kg diet), a 45% high-fat diet (HF, 1000 IU vitamin D/kg diet), or a 45% high-fat diet containing 25 IU vitamin D/kg diet (HF+LVD) for 12 weeks. The vitamin D-insufficient diet (HF+LVD) led to vitamin D inadequacy as determined by serum 25(OH) D level, 68.56 +/- 7w.97 nmol/L. The HF+LVD group exacerbated HF-increased adipocyte size, adipogenic gene expression of PPAR gamma, adipose tissue macrophage recruitment, and proinflammatory cytokine IL-6 and TNF alpha levels in epididymal white adipose tissue. In addition, vitamin D insufficiency significantly decreased mRNA levels of beta-oxidation-related genes such as CPT1 alpha, PGC1 alpha, PPAR alpha, VLCAD, LCAD, MCAD, and UCP1. Moreover, significant decrements of SIRT1 and AMPK activity were noted in obese rats fed with a vitamin D-insufficient diet. The observed deleterious effects of vitamin D insufficiency on adipose tissue expansion, immune cell infiltration and inflammatory status suggest vitamin D plays a beneficial role in adipocyte metabolic metabolism and obesity progression. SIRT1 and AMPK activity may play a role in the mechanism of vitamin D action.-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.subjectadenosine monophosphate-activated protein kinase (AMPK)-
dc.subjectadipose tissue macrophage infiltration-
dc.subjectobesity-
dc.subjectsirtulin 1 (SIRT1)-
dc.subjectvitamin D-
dc.titleVitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume9-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleNUTRIENTS-
dc.identifier.doi10.3390/nu9040338-
dc.identifier.wosidWOS:000401355600023-
dc.identifier.scopusid2-s2.0-85016467847-
dc.author.googleChang, Eugene-
dc.author.googleKim, Yangha-
dc.contributor.scopusid김양하(8524160300)-
dc.contributor.scopusid장유진(56459461000)-
dc.date.modifydate20210729142022-


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