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dc.contributor.author윤주영-
dc.contributor.author김진흥-
dc.date.accessioned2017-03-01T01:03:44Z-
dc.date.available2017-03-01T01:03:44Z-
dc.date.issued2017-
dc.identifier.issn1144-0546-
dc.identifier.issn1369-9261-
dc.identifier.otherOAK-20219-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/234627-
dc.description.abstractTwo new dinuclear iridium (Ir) complexes bridged by a conjugated aromatic tppz ligand, (bhq)(2)Ir(tppz)Ir(bhq)(2) (1) and (ppy)(2)Ir(tppz)Ir(ppy)(2) (2) (bhq = benzo(h)quinolone, ppy = phenyl-pyridine, tppz = tetrapyrido[ 3,2-a:2',3'-c:3 '',2 ''-h:2''',3'''-j] phenazine), were prepared. The DNA binding properties of complexes 1 and 2 were studied using single-stranded DNA, double-stranded DNA, and G-quadruplex DNA. G-Quadruplex binding was characterized by higher emission enhancements than those observed with other control DNA strands. Photophysical properties of complexes 1 and 2 indicated that 1 displayed selective G-quadruplex binding affinity, but 2 did not. The emission properties of complexes 1 and 2 were also studied using liposomes in order to understand their possible interactions with lipid-rich organelles in live cells. The phosphorescence intensity of 1 and 2 was enhanced upon interaction with liposomes, but 2 showed greater enhancement. We also confirmed that 1 and 2 could be used as probes in live cells. Complexes 1 and 2 were intensely stained in HeLa cervical cancer cells. Excitation with a lambda = 488 nm laser showed red emission localized in the cytosol of cells. Cellular studies showed that 1 and 2 were located inside HeLa cells, but neither complex passed through the nuclear membrane. However, complexes 1 and 2 possessed superior photostability, indicating their role as good luminescent agents for imaging and tracking the endoplasmic reticulum (ER) in live cells. Overall, complex 1 exhibited better selectivity for G-quadruplexes, liposomes, and ER staining.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleDiiridium(III) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume41-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage377-
dc.relation.lastpage386-
dc.relation.journaltitleNEW JOURNAL OF CHEMISTRY-
dc.identifier.doi10.1039/c6nj02890j-
dc.identifier.wosidWOS:000391451500043-
dc.author.googleAnjong, Tikum Florence-
dc.author.googleKim, Gyoungmi-
dc.author.googleJang, Ha Yoon-
dc.author.googleYoon, Juyoung-
dc.author.googleKim, Jinheung-
dc.contributor.scopusid윤주영(7403587371)-
dc.contributor.scopusid김진흥(8580015800)-
dc.date.modifydate20210929144142-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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