DSpace at EWHA: Stereoselective Synthesis of a Ceramide Transporter Protein (CERT)-Dependent Ceramide-Trafficking Inhibitor, (1R,3S)-HPA-12, via Gold(I)-Catalyzed Cyclization of a Propargylic N-Hydroxylamine

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DC Field	Value	Language
dc.contributor.author	류재상	*
dc.date.accessioned	2017-02-15T08:02:10Z	-
dc.date.available	2017-02-15T08:02:10Z	-
dc.date.issued	2017	*
dc.identifier.issn	0039-7881	*
dc.identifier.issn	1437-210X	*
dc.identifier.other	OAK-20111	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/234540	-
dc.description.abstract	A ceramide transporter protein (CERT)-dependent ceramide-trafficking inhibitor, HPA-12, is efficiently synthesized using gold(I)-catalyzed cyclization of a propargylic N-hydroxylamine, which is prepared via a stereoselective nitrone-alkyne addition reaction. The resulting 4-isoxazoline is converted into a syn-1,3-amino alcohol through stereoselective reduction and reductive ring opening.	*
dc.language	English	*
dc.publisher	GEORG THIEME VERLAG KG	*
dc.subject	HPA-12	*
dc.subject	gold	*
dc.subject	nitrone	*
dc.subject	4-isoxazoline	*
dc.subject	stereoselective synthesis	*
dc.title	Stereoselective Synthesis of a Ceramide Transporter Protein (CERT)-Dependent Ceramide-Trafficking Inhibitor, (1R,3S)-HPA-12, via Gold(I)-Catalyzed Cyclization of a Propargylic N-Hydroxylamine	*
dc.type	Article	*
dc.relation.issue	7	*
dc.relation.volume	49	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	1569	*
dc.relation.lastpage	1574	*
dc.relation.journaltitle	SYNTHESIS-STUTTGART	*
dc.identifier.doi	10.1055/s-0036-1588369	*
dc.identifier.wosid	WOS:000398467400013	*
dc.identifier.scopusid	2-s2.0-85006312494	*
dc.author.google	Chandrasekhar, Bandari	*
dc.author.google	Ahn, Sewon	*
dc.author.google	Ryu, Jae-Sang	*
dc.contributor.scopusid	류재상(36081118200)	*
dc.date.modifydate	20231120165709	*