Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원재 | * |
dc.contributor.author | 김재상 | * |
dc.contributor.author | 이대기 | * |
dc.date.accessioned | 2017-02-15T08:02:25Z | - |
dc.date.available | 2017-02-15T08:02:25Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0261-4189 | * |
dc.identifier.other | OAK-3482 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234082 | - |
dc.description.abstract | In the Drosophila gut, reactive oxygen species (ROS)-dependent immunity is critical to host survival. This is in contrast to the NF-κB pathway whose physiological function in the microbe-laden epithelia has yet to be convincingly demonstrated despite playing a critical role during systemic infections. We used a novel in vivo approach to reveal the physiological role of gut NF-κB/antimicrobial peptide (AMP) system, which has been 'masked' in the presence of the dominant intestinal ROS-dependent immunity. When fed with ROS-resistant microbes, NF-κB pathway mutant flies, but not wild-type flies, become highly susceptible to gut infection. This high lethality can be significantly reduced by either re-introducing Relish expression to Relish mutants or by constitutively expressing a single AMP to the NF-κB pathway mutants in the intestine. These results imply that the local 'NF-κB/AMP' system acts as an essential 'fail-safe' system, complementary to the ROS-dependent gut immunity, during gut infection with ROS-resistant pathogens. This system provides the Drosophila gut immunity the versatility necessary to manage sporadic invasion of virulent pathogens that somehow counteract or evade the ROS-dependent immunity. ©2006 European Molecular Biology Organization. | * |
dc.language | English | * |
dc.title | An essential complementary role of NF-κB pathway to microbicidal oxidants in Drosophila gut immunity | * |
dc.type | Article | * |
dc.relation.issue | 15 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3693 | * |
dc.relation.lastpage | 3701 | * |
dc.relation.journaltitle | EMBO Journal | * |
dc.identifier.doi | 10.1038/sj.emboj.7601233 | * |
dc.identifier.wosid | WOS:000239626000025 | * |
dc.identifier.scopusid | 2-s2.0-33747586778 | * |
dc.author.google | Ryu J.-H. | * |
dc.author.google | Ha E.-M. | * |
dc.author.google | Oh C.-T. | * |
dc.author.google | Seol J.-H. | * |
dc.author.google | Brey P.T. | * |
dc.author.google | Jin I. | * |
dc.author.google | Lee D.G. | * |
dc.author.google | Kim J. | * |
dc.author.google | Lee D. | * |
dc.author.google | Lee W.-J. | * |
dc.contributor.scopusid | 이원재(57171092600) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.contributor.scopusid | 이대기(37047040400) | * |
dc.date.modifydate | 20231120151223 | * |