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자연과학대학
화학·나노과학전공
Journal papers
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Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption
Title
Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption
Authors
Li Y.-J.
;
Kim T.-H.
;
Kwak H.B.
;
Lee Z.H.
;
Lee S.-Y.
;
Jhon G.-J.
Ewha Authors
전길자
;
이수영
SCOPUS Author ID
전길자
; 이수영
Issue Date
2007
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Citation
Journal of Ethnopharmacology vol. 113, no. 2, pp. 191 - 198
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
It has been reported that deer antler extract has anti-bone resorptive activity in vivo. However, little is known about the cellular and molecular mechanism of this effect. In this study, we investigated the effects of deer antler extracts on osteoclast differentiation and bone-resorption in vitro. Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-κB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF). CE-C suppressed the activation of extracellular signal-regulated kinase (ERK), protein kinase B (PKB/Akt) and inhibitor of kappa B (I-κB) by RANKL in osteoclast precursor cells. It also inhibited the bone resorptive activity of differentiated osteoclasts that was accompanied by disruption of actin rings and induction of the apoptosis. These results demonstrate deer antler extract may be a useful remedy for the treatment of bone-resorption diseases such as osteoporosis. © 2007 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.jep.2007.04.020
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