Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2017-01-14T02:01:48Z | - |
dc.date.available | 2017-01-14T02:01:48Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1021-335X | * |
dc.identifier.issn | 1791-2431 | * |
dc.identifier.other | OAK-19965 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233879 | - |
dc.description.abstract | The B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) protein is activated in various types of tumors and associated with cancer development and tumor progression. However, the working role of BMI-1 in cellular signaling is not understood completely. In this study, we revealed one possible biologic mechanism of BMI-1 in cancer progression in vitro using a human ovarian tumor cell system. Suppressor of MEK1 (sMEK1), a pivotal regulator involved in the cellular biological response mechanism, was identified as a BMI-1-binding protein. Ectopic expression of BMI-1 activated cell growth by reducing sMEK1-stimulated apoptotic cell death and suppressing p21, p27 and p53 expression, while enhancing cyclin Dl, CDK4 and Bcl-2 expression. The effect of BMI-1 on cell cycle and apoptotic regulatory proteins was also confirmed via silencing of BMI-1 expression. Subsequently, the promoter activities of p21 and p53 were inactivated significantly. However, BMI-1 overexpression noticeably increased Bcl-2 and NF-kappa B activities. In addition, BMI-1 activated the PI3K/mTOR/4E-BP1 signaling pathways, and sMEK1 significantly inhibited BMI-1-stimulated oncogenesis. These insights provide evidence that BMI-1 activates cell growth and suppresses apoptosis. Collectively, our data indicate that BMI-1 plays a pivotal role in the progression of ovarian cancer, thus representing a novel target for antitumor therapy of ovarian cancer. | * |
dc.language | English | * |
dc.publisher | SPANDIDOS PUBL LTD | * |
dc.subject | BMI-1 | * |
dc.subject | sMEK1 | * |
dc.subject | protein-protein interaction | * |
dc.subject | pro-apoptotic activity | * |
dc.subject | ovarian tumor metastasis | * |
dc.title | BMI-1 interacts with sMEK1 and inactivates sMEK1-induced apoptotic cell death | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 579 | * |
dc.relation.lastpage | 586 | * |
dc.relation.journaltitle | ONCOLOGY REPORTS | * |
dc.identifier.doi | 10.3892/or.2016.5262 | * |
dc.identifier.wosid | WOS:000390639800069 | * |
dc.identifier.scopusid | 2-s2.0-85006340453 | * |
dc.author.google | Kim, Boh-Ram | * |
dc.author.google | Kwon, Youngjoo | * |
dc.author.google | Rho, Seung Bae | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |