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First synthesis of 4′-selenonucleosides showing unusual southern conformation

Title
First synthesis of 4′-selenonucleosides showing unusual southern conformation
Authors
Lak S.J.Tosh D.K.Hea O.K.Wang T.Hou X.Ho S.Y.Kwon Y.Sang K.L.Choi J.Long X.Z.
Ewha Authors
정낙신이상국권영주
SCOPUS Author ID
정낙신scopus; 이상국scopus; 권영주scopusscopus
Issue Date
2008
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
Organic Letters vol. 10, no. 2, pp. 209 - 212
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
(Chemical Equation Presented) The first synthesis of 4′- selenonucleosides was achieved using a Pummerer-type condensation as a key step. All stereoelectronic effects shown in 4′-oxonucleosides were overwhelmed by the size of selenium and steric interactions, driving the conformation to the C2′-endo/C3′-exo twist (Southern) conformation. © 2008 American Chemical Society.
DOI
10.1021/ol7025558
Appears in Collections:
약학대학 > 약학과 > Journal papers
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