Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2017-01-06T02:01:40Z | - |
dc.date.available | 2017-01-06T02:01:40Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-4551 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233802 | - |
dc.description.abstract | Matrix metalloproteinase-9 (MMP-9) plays an important role in mediating the invasion and angiogenic process of malignant gliomas. This study was undertaken to determine if an isoflavone metabolite, irisolidone, inhibits MMP-9 expression in human astroglioma cells. Irisolidone was found to inhibit the secretion and protein expression of MMP-9 induced by PMA in U87 MG glioma cells, accompanied by the inhibition of MMP-9 mRNA expression and promoter activity. Further mechanistic studies revealed that irisolidone inhibits the binding of NF-κB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of ERK and JNK, which are upstream signaling molecules in MMP-9 expression. The Matrigel-invasion assay showed that irisolidone suppresses the in vitro invasiveness of glioma cells. Therefore, the strong inhibition of MMP-9 expression by irisolidone might be a potential therapeutic modality for controlling the growth and invasiveness of gliomas. © 2007 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Inhibition of matrix metalloproteinase-9 gene expression by an isoflavone metabolite, irisolidone in U87MG human astroglioma cells | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 366 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 493 | * |
dc.relation.lastpage | 499 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2007.11.178 | * |
dc.identifier.wosid | WOS:000252436300036 | * |
dc.identifier.scopusid | 2-s2.0-37449034845 | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Lee E.-J. | * |
dc.author.google | Woo M.-S. | * |
dc.author.google | Jung J.-S. | * |
dc.author.google | Hyun J.-W. | * |
dc.author.google | Min S.-W. | * |
dc.author.google | Kim D.-H. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |