DSpace at EWHA: Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-β type1 receptor kinase inhibitors

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DC Field	Value	Language
dc.contributor.author	김대기	*
dc.date.accessioned	2017-01-05T02:01:00Z	-
dc.date.available	2017-01-05T02:01:00Z	-
dc.date.issued	2008	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-4685	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/233557	-
dc.description.abstract	A series of 5-(pyridin-2-yl)thiazoles (14a-l and 15a-l) has been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 3-[[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl ]benzamide (15i) and 3-[[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl] benzamide (15k) showed more than 95% inhibition at 0.1 μM in luciferase reporter assays using HaCaT cells transiently transfected with p3TP-luc reporter construct and ARE-luciferase reporter construct. © 2008 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-β type1 receptor kinase inhibitors	*
dc.type	Article	*
dc.relation.issue	6	*
dc.relation.volume	18	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	2122	*
dc.relation.lastpage	2127	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2008.01.084	*
dc.identifier.wosid	WOS:000254180300069	*
dc.identifier.scopusid	2-s2.0-40849097867	*
dc.author.google	Kim D.-K.	*
dc.author.google	Choi J.H.	*
dc.author.google	An Y.J.	*
dc.author.google	Lee H.S.	*
dc.contributor.scopusid	김대기(35083694200)	*
dc.date.modifydate	20240118164500	*