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Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
- Title
- Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
- Authors
- Lee, Tae Hee; Cha, Sun-Shin; Lee, Chang-Seop; Rhee, Joon Haeng; Woo, Hye Ryun; Chung, Kyung Min
- Ewha Authors
- 차선신
- SCOPUS Author ID
- 차선신
- Issue Date
- 2016
- Journal Title
- MICROBIOLOGY AND IMMUNOLOGY
- ISSN
- 0385-5600
1348-0421
- Citation
- MICROBIOLOGY AND IMMUNOLOGY vol. 60, no. 11, pp. 793 - 800
- Keywords
- cross-protection; MARTX toxin; monoclonal antibody; Vibrio species
- Publisher
- WILEY-BLACKWELL
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTX(Vv) was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTX(Vc), inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins.
- DOI
- 10.1111/1348-0421.12449
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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