Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이화정 | * |
dc.date.accessioned | 2016-12-06T02:12:24Z | - |
dc.date.available | 2016-12-06T02:12:24Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0269-4727 | * |
dc.identifier.other | OAK-5059 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232999 | - |
dc.description.abstract | Background and objective: Genetic polymorphism of CYP2D6 leads to differences in pharmacokinetics of CYP2D6 substrates. The CYP2D6*10 allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the CYP2D6*10 allele in Korean subjects. Methods: One hundred and seven volunteers were recruited and grouped as CYP2D6*1/*1, CYP2D6*1/*10 and CYP2D6*10/*10 according to their genotypes. Metoprolol tartrate 100 mg (Betaloc®) was administered orally once to each subject in these three groups (n = 6, 7 and 5, respectively). The pharmacokinetic parameters of metoprolol and its metabolite, α-hydroxymetoprolol, and the metabolic ratio for the three groups were estimated and compared. Results and discussion: The area under the plasma concentration-time curve (AUC0→∞), the maximum plasma concentration (Cmax) and the elimination half-life (T1/2) of metoprolol and α-hydroxymetoprolol for the CYP2D6*10/*10 group were all significantly different from those of the CYP2D6*1/*1 group (P < 0.05). The AUC0→∞s of metoprolol were 443.7 ± 168.1, 995.6 ± 321.4 and 2545.3 ± 632.0 ng.h/mL, and the AUC0→∞s of α-hydroxymetoprolol were 1232.0 ± 311.2, 1344.0 ± 288.1 and 877.4 ± 103.4 ng.h/mL for groups CYP2D6*1/*1, *1/*10 and *10/*10, respectively. The corresponding T1/2 values of metoprolol were 2.7 ± 0.5, 3.2 ± 1.3 and 5.0 ± 1.1 h, while those of α-hydroxymetoprolol were 5.4±1.5, 6.0 ± 1.4 and 10.5 ± 4.2 h, respectively. The metabolic ratios of the three groups were significantly different (P < 0.05). Conclusion: The CYP2D6*10 allele altered the pharmacokinetics of metoprolol in Korean subjects and is likely to affect other drugs metabolized by the CYP2D6 enzyme, similarly. © 2008 The Authors. | * |
dc.language | English | * |
dc.title | Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 567 | * |
dc.relation.lastpage | 573 | * |
dc.relation.journaltitle | Journal of Clinical Pharmacy and Therapeutics | * |
dc.identifier.doi | 10.1111/j.1365-2710.2008.00945.x | * |
dc.identifier.wosid | WOS:000259310000015 | * |
dc.identifier.scopusid | 2-s2.0-52049120158 | * |
dc.author.google | Jin S.K. | * |
dc.author.google | Chung H.J. | * |
dc.author.google | Chung M.W. | * |
dc.author.google | Kim J.-I. | * |
dc.author.google | Kang J.-H. | * |
dc.author.google | Woo S.W. | * |
dc.author.google | Bang S. | * |
dc.author.google | Lee S.H. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Roh J. | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.date.modifydate | 20240118154655 | * |