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dc.contributor.author손연수-
dc.contributor.author이화정-
dc.contributor.author정병문-
dc.date.accessioned2016-11-30T02:11:30Z-
dc.date.available2016-11-30T02:11:30Z-
dc.date.issued2008-
dc.identifier.issn0960-894X-
dc.identifier.otherOAK-5229-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/232904-
dc.description.abstractA novel water soluble and biodegradable cyclotriphosphazene-paclitaxel conjugate was prepared by reacting 2′-succinyl paclitaxel with cyclotriphosphazenes bearing equimolar glycyl-l-lysine and methoxy poly(ethylene glycol) as side groups. The macromolecular conjugate was found to self-assemble in aqueous solution to form stable micelles with a mean hydrodynamic diameter of 24.7 nm and a low critical micelle concentration of 10 mg/L. The present conjugate exhibited lower than free paclitaxel but reasonably high in vitro cytotoxicity against selected human tumor cells due to their hydrolytic degradation in PBS solution. © 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleA micellar prodrug of paclitaxel conjugated to cyclotriphosphazene-
dc.typeArticle-
dc.relation.issue24-
dc.relation.volume18-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage6410-
dc.relation.lastpage6413-
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters-
dc.identifier.doi10.1016/j.bmcl.2008.10.077-
dc.identifier.wosidWOS:000261141100024-
dc.identifier.scopusid2-s2.0-56249084206-
dc.author.googleJun Y.J.-
dc.author.googleMin J.H.-
dc.author.googleJi D.E.-
dc.author.googleYoo J.H.-
dc.author.googleKim J.H.-
dc.author.googleLee H.J.-
dc.author.googleJeong B.-
dc.author.googleSohn Y.S.-
dc.contributor.scopusid손연수(7201971323)-
dc.contributor.scopusid이화정(57102029300)-
dc.contributor.scopusid정병문(7102237959)-
dc.date.modifydate20220119154825-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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