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Glycogen synthase kinase 3 beta in Toll-like receptor signaling
- Title
- Glycogen synthase kinase 3 beta in Toll-like receptor signaling
- Authors
- Ko, Ryeojin; Lee, Soo Young
- Ewha Authors
- 이수영
- SCOPUS Author ID
- 이수영
- Issue Date
- 2016
- Journal Title
- BMB REPORTS
- ISSN
- 1976-6696
1976-670X
- Citation
- BMB REPORTS vol. 49, no. 6, pp. 305 - 310
- Keywords
- Glycogen synthase kinase 3 beta (GSK3 beta); Inflammatory cytokines; Toll-like receptor (TLR); Type I interferons (IFNs)
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY &
MOLECULAR BIOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Toll-like receptors (TLRs) play a critical role in the innate immune response against pathogens. Each TLR recognizes specific pathogen-associated molecular patterns, after which they activate the adaptor protein MyD88 or TRIF-assembled signaling complex to produce immune mediators, including inflammatory cytokines and type I IFNs. Although the activation of TLR is important for host defense, its uncontrolled activation can damage the host. During the past decade, numerous studies have demonstrated that GSK3 beta is a key regulator of inflammatory cytokine production in MyD88-mediated TLR signaling via TLR2 and TLR4. Recently, GSK3 beta has also been implicated in the TRIF-dependent signaling pathway via TLR3. In this review, we describe current advances on the regulatory role of GSK3 beta in immune responses associated with various TLRs. A better understanding of the role of GSK3 beta. in TLR signaling might lead to more effective anti-inflammatory interventions.
- DOI
- 10.5483/BMBRep.2016.49.6.059
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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