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dc.contributor.author김대기-
dc.date.accessioned2016-10-20T02:10:34Z-
dc.date.available2016-10-20T02:10:34Z-
dc.date.issued2009-
dc.identifier.issn0223-5234-
dc.identifier.otherOAK-5489-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/232502-
dc.description.abstractA series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38α MAP kinase activity only 11 and 8% at a concentration of 10 μM, respectively. © 2008 Elsevier Masson SAS. All rights reserved.-
dc.languageEnglish-
dc.titleSynthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume44-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage568-
dc.relation.lastpage576-
dc.relation.journaltitleEuropean Journal of Medicinal Chemistry-
dc.identifier.doi10.1016/j.ejmech.2008.03.024-
dc.identifier.wosidWOS:000264407800014-
dc.identifier.scopusid2-s2.0-60349088674-
dc.author.googleKim D.-K.-
dc.author.googleJung S.H.-
dc.author.googleLee H.S.-
dc.author.googleDewang P.M.-
dc.contributor.scopusid김대기(35083694200)-
dc.date.modifydate20220303081001-
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약학대학 > 약학과 > Journal papers
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