Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-10-20T02:10:34Z | - |
dc.date.available | 2016-10-20T02:10:34Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-5489 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232502 | - |
dc.description.abstract | A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38α MAP kinase activity only 11 and 8% at a concentration of 10 μM, respectively. © 2008 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 568 | * |
dc.relation.lastpage | 576 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2008.03.024 | * |
dc.identifier.wosid | WOS:000264407800014 | * |
dc.identifier.scopusid | 2-s2.0-60349088674 | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Jung S.H. | * |
dc.author.google | Lee H.S. | * |
dc.author.google | Dewang P.M. | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |