Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한평림 | * |
dc.contributor.author | 이강우 | * |
dc.contributor.author | 김경심 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2016-10-20T02:10:33Z | - |
dc.date.available | 2016-10-20T02:10:33Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0006-8993 | * |
dc.identifier.other | OAK-5505 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232493 | - |
dc.description.abstract | SK-PC-B70M is an oleanolic-glycoside saponin-enriched fraction derived from the root of Pulsatilla koreana. Recently, it was reported that hederacolchiside-E is an active ingredient of SK-PC-B70M that confers a neuroprotective effect against the cytotoxicity induced by Aβ(1-42) in SK-N-SH neuroblastoma cells. SK-PC-B70M improves scopolamine-induced impairments of spatial working memory in rats. In the present study, we investigated whether SK-PC-B70M has a beneficial effect on the Tg2576 murine model of Alzheimer's disease. ELISA analysis revealed that the levels of soluble and insoluble forms of Aβ(1-42) in Tg2576 mice fed SK-PC-B70M (2000 ppm) from 11 months to 16 months of age were reduced to, respectively, 66% and 79% of the control Tg2576 mice. Anti-Aβ antibody-stained brain sections of Tg2576 mice with SK-PC-B70M (2000 ppm) consistently showed a reduction in plaque formation in the brain. Western blot analyses showed altered expressions of various cellular factors, such as up-regulation of transthyretin, phospho-ERK, and phospho-CREB in the brain treated with SK-PC-B70M. SK-PC-B70M suppressed the neuronal toxicity induced by H2O2 in primary cortical culture. Moreover, biochemical and immunohistochemical analyses showed that the levels of malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE), oxidized by-products of lipid peroxidation, were notably reduced in the hippocampus of Tg2576 mice treated with SK-PC-B70M compared with the Tg2576 control. These results suggest that SK-PC-B70M attenuates AD-like pathology in the brain of Tg2576 mice. © 2008 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | SK-PC-B70M confers anti-oxidant activity and reduces Aβ levels in the brain of Tg2576 mice | * |
dc.type | Article | * |
dc.relation.volume | 1261 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 100 | * |
dc.relation.lastpage | 108 | * |
dc.relation.journaltitle | Brain Research | * |
dc.identifier.doi | 10.1016/j.brainres.2009.01.019 | * |
dc.identifier.wosid | WOS:000264693300012 | * |
dc.identifier.scopusid | 2-s2.0-61849182567 | * |
dc.author.google | Seo J.-S. | * |
dc.author.google | Kim T.-K. | * |
dc.author.google | Leem Y.-H. | * |
dc.author.google | Lee K.-W. | * |
dc.author.google | Park S.-K. | * |
dc.author.google | Baek I.-S. | * |
dc.author.google | Kim K.-S. | * |
dc.author.google | Im G.-J. | * |
dc.author.google | Lee S.M. | * |
dc.author.google | Park Y.H. | * |
dc.author.google | Han P.-L. | * |
dc.contributor.scopusid | 한평림(7201947605) | * |
dc.contributor.scopusid | 이강우(55737459200) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |