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dc.contributor.author장준*
dc.date.accessioned2016-10-15T01:10:23Z-
dc.date.available2016-10-15T01:10:23Z-
dc.date.issued2009*
dc.identifier.issn0006-4971*
dc.identifier.otherOAK-5600*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/232420-
dc.description.abstractIn contrast to previous notions of the help-independency of memory CD8 T cells during secondary expansion, here we show that CD4 help is indispensable for the re-expansion of once-helped memory CD8 T cells, using a hematopoietic cell-specific dominant minor histocompatibility (H) antigen, H60, as a model antigen. H60-specific memory CD8 T cells generated during a helped primary response vigorously expanded only when rechallenged under helped conditions. The help requirement for an optimal secondary response was confirmed by a reduction in peak size by CD4 depletion, and was reproduced after skin transplantation. Helpless conditions or noncognate separate help during the secondary response resulted in a significant reduction in the peak size and different response kinetics. Providing CD4 help again during a tertiary challenge restored robust memory expansion; however, the repeated deprivation of help further reduced clonal expansion. Adoptively transferred memory CD8 T cells did not proliferate in CD40L -/- hosts. In the CD40 -/- hosts, marginal memory expansion was detected after priming with male H60 cells but was completely abolished by priming with peptide-loaded CD40 -/- cells, suggesting the essential role of CD40 and CD40L in memory responses. These results provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response. © 2009 by The American Society of Hematology.*
dc.languageEnglish*
dc.titleCognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60*
dc.typeArticle*
dc.relation.issue18*
dc.relation.volume113*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage4273*
dc.relation.lastpage4280*
dc.relation.journaltitleBlood*
dc.identifier.doi10.1182/blood-2008-09-181263*
dc.identifier.wosidWOS:000265846300023*
dc.identifier.scopusid2-s2.0-66149134434*
dc.author.googleSu J.R.*
dc.author.googleKyung M.J.*
dc.author.googleHyun S.Y.*
dc.author.googleTae W.K.*
dc.author.googleSol K.*
dc.author.googleJun C.*
dc.author.googleEun Y.C.*
dc.contributor.scopusid장준(8735999100)*
dc.date.modifydate20231120165756*
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약학대학 > 약학과 > Journal papers
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