Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2016-10-15T01:10:23Z | - |
dc.date.available | 2016-10-15T01:10:23Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0006-4971 | * |
dc.identifier.other | OAK-5600 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232420 | - |
dc.description.abstract | In contrast to previous notions of the help-independency of memory CD8 T cells during secondary expansion, here we show that CD4 help is indispensable for the re-expansion of once-helped memory CD8 T cells, using a hematopoietic cell-specific dominant minor histocompatibility (H) antigen, H60, as a model antigen. H60-specific memory CD8 T cells generated during a helped primary response vigorously expanded only when rechallenged under helped conditions. The help requirement for an optimal secondary response was confirmed by a reduction in peak size by CD4 depletion, and was reproduced after skin transplantation. Helpless conditions or noncognate separate help during the secondary response resulted in a significant reduction in the peak size and different response kinetics. Providing CD4 help again during a tertiary challenge restored robust memory expansion; however, the repeated deprivation of help further reduced clonal expansion. Adoptively transferred memory CD8 T cells did not proliferate in CD40L -/- hosts. In the CD40 -/- hosts, marginal memory expansion was detected after priming with male H60 cells but was completely abolished by priming with peptide-loaded CD40 -/- cells, suggesting the essential role of CD40 and CD40L in memory responses. These results provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response. © 2009 by The American Society of Hematology. | * |
dc.language | English | * |
dc.title | Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60 | * |
dc.type | Article | * |
dc.relation.issue | 18 | * |
dc.relation.volume | 113 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4273 | * |
dc.relation.lastpage | 4280 | * |
dc.relation.journaltitle | Blood | * |
dc.identifier.doi | 10.1182/blood-2008-09-181263 | * |
dc.identifier.wosid | WOS:000265846300023 | * |
dc.identifier.scopusid | 2-s2.0-66149134434 | * |
dc.author.google | Su J.R. | * |
dc.author.google | Kyung M.J. | * |
dc.author.google | Hyun S.Y. | * |
dc.author.google | Tae W.K. | * |
dc.author.google | Sol K. | * |
dc.author.google | Jun C. | * |
dc.author.google | Eun Y.C. | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |