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An overview of rapamycin: from discovery to future perspectives

Title
An overview of rapamycin: from discovery to future perspectives
Authors
Yoo, Young JiKim, HanseongPark, Sung RyeolYoon, Yeo Joon
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2017
Journal Title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN
1367-5435JCR Link

1476-5535JCR Link
Citation
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY vol. 44, no. 42830.0, pp. 537 - 553
Keywords
RapamycinBiological activityMechanism of actionBiosynthesisProduction enhancement
Publisher
SPRINGER HEIDELBERG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of rapamycin is derived from (4R,5R)-4,5-dihydrocyclohex-1-ene-carboxylic acid that is extended by polyketide synthase. The resulting linear polyketide chain is cyclized by incorporating pipecolate and further decorated by post-PKS modification enzymes. Herein, we review the discovery and biological activities of rapamycin as well as its mechanism of action, mechanistic target, biosynthesis, and regulation. In addition, we introduce the many efforts directed at enhancing the production of rapamycin and generating diverse analogs and also explore future perspectives in rapamycin research. This review will also emphasize the remarkable pilot studies on the biosynthesis and production improvement of rapamycin by Dr. Demain, one of the world's distinguished scientists in industrial microbiology and biotechnology.
DOI
10.1007/s10295-016-1834-7
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자연과학대학 > 화학·나노과학전공 > Journal papers
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