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An overview of rapamycin: from discovery to future perspectives
- Title
- An overview of rapamycin: from discovery to future perspectives
- Authors
- Yoo, Young Ji; Kim, Hanseong; Park, Sung Ryeol; Yoon, Yeo Joon
- Ewha Authors
- 윤여준
- SCOPUS Author ID
- 윤여준
- Issue Date
- 2017
- Journal Title
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- ISSN
- 1367-5435
1476-5535
- Citation
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY vol. 44, no. 42830.0, pp. 537 - 553
- Keywords
- Rapamycin; Biological activity; Mechanism of action; Biosynthesis; Production enhancement
- Publisher
- SPRINGER HEIDELBERG
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of rapamycin is derived from (4R,5R)-4,5-dihydrocyclohex-1-ene-carboxylic acid that is extended by polyketide synthase. The resulting linear polyketide chain is cyclized by incorporating pipecolate and further decorated by post-PKS modification enzymes. Herein, we review the discovery and biological activities of rapamycin as well as its mechanism of action, mechanistic target, biosynthesis, and regulation. In addition, we introduce the many efforts directed at enhancing the production of rapamycin and generating diverse analogs and also explore future perspectives in rapamycin research. This review will also emphasize the remarkable pilot studies on the biosynthesis and production improvement of rapamycin by Dr. Demain, one of the world's distinguished scientists in industrial microbiology and biotechnology.
- DOI
- 10.1007/s10295-016-1834-7
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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