Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경효 | * |
dc.contributor.author | 김한울 | * |
dc.contributor.author | 박인호 | * |
dc.date.accessioned | 2016-10-14T01:10:51Z | - |
dc.date.available | 2016-10-14T01:10:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.other | OAK-19390 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232386 | - |
dc.description.abstract | The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier. © Yonsei University College of Medicine 2016. | * |
dc.language | English | * |
dc.publisher | Yonsei University College of Medicine | * |
dc.subject | Meningococcal vaccine | * |
dc.subject | Neisseria meningitidis | * |
dc.subject | Serum bactericidal antibody assay | * |
dc.title | Immunogenicity of menACWY-CRM in Korean military recruits: Influence of tetanus-diphtheria toxoid vaccination on the vaccine response to menACWY-CRM | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1511 | * |
dc.relation.lastpage | 1516 | * |
dc.relation.journaltitle | Yonsei Medical Journal | * |
dc.identifier.doi | 10.3349/ymj.2016.57.6.1511 | * |
dc.identifier.wosid | WOS:000388219600030 | * |
dc.identifier.scopusid | 2-s2.0-84986917897 | * |
dc.author.google | Kim H.W. | * |
dc.author.google | Park I.H. | * |
dc.author.google | You S. | * |
dc.author.google | Yu H.T. | * |
dc.author.google | Oh I.S. | * |
dc.author.google | Sung P.S. | * |
dc.author.google | Shin E.C. | * |
dc.author.google | Kim K.H. | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.contributor.scopusid | 김한울(43161180100) | * |
dc.contributor.scopusid | 박인호(57191108169) | * |
dc.date.modifydate | 20240301081003 | * |