Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-29T11:08:48Z | - |
dc.date.available | 2016-08-29T11:08:48Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0014-2999 | * |
dc.identifier.other | OAK-5775 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232002 | - |
dc.description.abstract | Poria cocos Wolf (P. cocos Wolf) is used to treat chronic gastritis, edema, nephrosis, gastric atony, acute gastroenteric catarrh, dizziness, emesis and vomiting. Triterpenoids are a class of natural compounds produced by P. cocos Wolf that contain acyclic 30-carbon precursors. In this study, we investigated the effect of triterpenoids (PA, Pachymic acid; DA, dehydroeburicoic acid; HA, 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid) on human 5-hydroxytryptamine 3A (5-HT 3A) receptor channel activity, which is one of the ligand-gated ion channel families. The two-electrode voltage-clamp technique was used to examine the 5-HT3A mediated current. The inhibitory effect of triterpenoids on 5HT-induced inward current (I 5-HT) occurred in a concentration dependent and reversible manner. Furthermore, the half-inhibitory concentrations (IC 50) of PA, DA and HA were 3.2 ± 0.2, 5.5 ± 0.6 and 1.4 ± 0.2 μM, respectively. This corresponded to an order of potency for the inhibition of I 5-HT in oocytes expressing human 5-HT 3A receptor of HA > PA > DA. Finally, inhibition of I 5HT by triterpenoids occurred in a non-competitive manner, while inhibition by HA and PA showed more voltage-dependency. Taken together, these results indicate that triterpenoids may regulate the expressed 5-HT 3A receptors in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of P. cocos Wolf. © 2009 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes | * |
dc.type | Article | * |
dc.relation.issue | 41277 | * |
dc.relation.volume | 615 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 27 | * |
dc.relation.lastpage | 32 | * |
dc.relation.journaltitle | European Journal of Pharmacology | * |
dc.identifier.doi | 10.1016/j.ejphar.2009.04.063 | * |
dc.identifier.wosid | WOS:000268218100004 | * |
dc.identifier.scopusid | 2-s2.0-67449152244 | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Lee Y.J. | * |
dc.author.google | Shin J.-K. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Nah S.-Y. | * |
dc.author.google | Kim S.-H. | * |
dc.author.google | Jeong J.-H. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Shin M. | * |
dc.author.google | Hong M. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Bae H. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |