Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전길자 | * |
dc.contributor.author | 이상혁 | * |
dc.contributor.author | 배윤수 | * |
dc.contributor.author | 김재상 | * |
dc.contributor.author | 임진경 | * |
dc.date.accessioned | 2016-08-29T11:08:27Z | - |
dc.date.available | 2016-08-29T11:08:27Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1420-682X | * |
dc.identifier.other | OAK-5759 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231993 | - |
dc.description.abstract | The regulation of megakaryocytic differentiation is poorly understood. Using K562 cells, which can partly recapitulate the process in response to phorbol 12-myristate 13-acetate (PMA), we performed microarray-based gene expression profiling to identify genes that play significant roles in megakaryopoiesis. Here, we describe the function of FosB, an AP-1 transcription factor. FosB is induced in PMA treated K562 cells in a sustained manner and forms an active AP-1 protein-DNA complex. Down-regulation of FosB with specific shRNAs inhibited the induction of CD41, a specific cell surface marker of megakaryocytes. We also show that activation of the PKC-MEK-ERK signaling pathway is required for induction of FosB and CD41. Finally,we cross-examined the microarray data in conjunction with gene function annotation data to identify additional target genes of FosB. We define 3 genes, INHBA, CD9, and ITGA2B as regulatory targets of FosB and show that CD9, in particular, is a direct target of FosB. © Birkhäuser Verlag, 2009. | * |
dc.language | English | * |
dc.title | Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors | * |
dc.type | Article | * |
dc.relation.issue | 41590 | * |
dc.relation.volume | 66 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1962 | * |
dc.relation.lastpage | 1973 | * |
dc.relation.journaltitle | Cellular and Molecular Life Sciences | * |
dc.identifier.doi | 10.1007/s00018-009-8775-5 | * |
dc.identifier.wosid | WOS:000268004300015 | * |
dc.identifier.scopusid | 2-s2.0-70349339321 | * |
dc.author.google | Limb J.-K. | * |
dc.author.google | Yoon S. | * |
dc.author.google | Lee K.E. | * |
dc.author.google | Kim B.-H. | * |
dc.author.google | Lee S. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Jhon G.-J. | * |
dc.author.google | Kim J. | * |
dc.contributor.scopusid | 전길자(6701488476) | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.contributor.scopusid | 임진경(7003530407) | * |
dc.date.modifydate | 20240415122632 | * |