Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽혜선 | * |
dc.date.accessioned | 2016-08-29T11:08:17Z | - |
dc.date.available | 2016-08-29T11:08:17Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0305-7453 | * |
dc.identifier.other | OAK-5755 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231989 | - |
dc.description.abstract | Background: Although previous studies have suggested that linezolid may be effective for treating multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB), the optimal dose of linezolid for intractable MDR/XDR-TB is not clear. Methods: Twenty-four patients with intractable MDR/XDR-TB were treated with a daily 300 mg dose of linezolid as part of their anti-TB drug regimen. Results: The patients were treated with linezolid for a median duration of 359 days [interquartile range (IQR) 268-443 days]. Seventeen (71%) patients received 300 mg of linezolid once daily from the beginning of treatment for a median duration of 289 days (IQR 233-405 days). Of these patients, four developed peripheral neuropathy, one of whom discontinued linezolid. In seven (29%) patients, 600 mg/day linezolid was administered initially for a median duration of 104 days (IQR 26-145 days) followed by 300 mg/day linezolid for a median duration of 348 days (IQR 298-427 days). In five of these seven patients, the reason for changing from 600 to 300 mg/day was due to side effects of 600 mg/day linezolid (peripheral neuropathy in four patients and leucopenia in one patient). After reducing the dose to 300 mg/day, linezolid could be continued in six of the seven patients. Negative sputum conversion was achieved in 22 (92%) patients after a median of 89 days from the start of linezolid treatment (IQR 48-160 days). Conclusions: A daily 300 mg dose of linezolid may be useful for increasing the chances of culture conversion in the treatment of patients with intractable MDR/XDR-TB and might have fewer side effects, especially neurotoxicity, compared with a daily 600 mg dose of linezolid therapy. The present results encourage further research into the use of a 300 mg dose of linezolid for MDR/XDR-TB patients. © The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. | * |
dc.language | English | * |
dc.title | Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 64 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 388 | * |
dc.relation.lastpage | 391 | * |
dc.relation.journaltitle | Journal of Antimicrobial Chemotherapy | * |
dc.identifier.doi | 10.1093/jac/dkp171 | * |
dc.identifier.wosid | WOS:000267888800030 | * |
dc.identifier.scopusid | 2-s2.0-67650730258 | * |
dc.author.google | Koh W.-J. | * |
dc.author.google | Kwon O.J. | * |
dc.author.google | Gwak H. | * |
dc.author.google | Chung J.W. | * |
dc.author.google | Cho S.-N. | * |
dc.author.google | Kim W.S. | * |
dc.author.google | Shim T.S. | * |
dc.date.modifydate | 20240422115307 | * |