Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박은미 | * |
dc.date.accessioned | 2016-08-29T11:08:42Z | - |
dc.date.available | 2016-08-29T11:08:42Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0165-5728 | * |
dc.identifier.other | OAK-5635 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231926 | - |
dc.description.abstract | In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-κB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases. © 2009 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Anti-inflammatory mechanism of ginseng saponins in activated microglia | * |
dc.type | Article | * |
dc.relation.issue | 41276 | * |
dc.relation.volume | 209 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 40 | * |
dc.relation.lastpage | 49 | * |
dc.relation.journaltitle | Journal of Neuroimmunology | * |
dc.identifier.doi | 10.1016/j.jneuroim.2009.01.020 | * |
dc.identifier.wosid | WOS:000266299900005 | * |
dc.identifier.scopusid | 2-s2.0-64549126462 | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Park E.-M. | * |
dc.author.google | Kim D.-H. | * |
dc.author.google | Jung K. | * |
dc.author.google | Jung J.-S. | * |
dc.author.google | Lee E.-J. | * |
dc.author.google | Hyun J.-W. | * |
dc.author.google | Kang J.L. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박은미(35933416400) | * |
dc.date.modifydate | 20240123095000 | * |