Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 홍영미 | * |
dc.date.accessioned | 2016-08-29T11:08:23Z | - |
dc.date.available | 2016-08-29T11:08:23Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0271-9142 | * |
dc.identifier.other | OAK-5379 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231894 | - |
dc.description.abstract | Background: Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children. Methods: The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method. Results: The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism. Conclusions: Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm. © 2008 Springer Science+Business Media, LLC. | * |
dc.language | English | * |
dc.title | The CCR5 (-2135C/T) polymorphism may be associated with the development of kawasaki disease in Korean children | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 22 | * |
dc.relation.lastpage | 28 | * |
dc.relation.journaltitle | Journal of Clinical Immunology | * |
dc.identifier.doi | 10.1007/s10875-008-9218-z | * |
dc.identifier.wosid | WOS:000262987100003 | * |
dc.identifier.scopusid | 2-s2.0-59449086241 | * |
dc.author.google | Jhang W.K. | * |
dc.author.google | Kang M.-J. | * |
dc.author.google | Jin H.-S. | * |
dc.author.google | Yu J. | * |
dc.author.google | Kim B.-J. | * |
dc.author.google | Kim B.S. | * |
dc.author.google | Lee J.-K. | * |
dc.author.google | Seo E.-J. | * |
dc.author.google | Yoo H.-W. | * |
dc.author.google | Park I.S. | * |
dc.author.google | Hong Y.M. | * |
dc.author.google | Hong S.-J. | * |
dc.contributor.scopusid | 홍영미(35210025100;57327441600;55841904000;56063366100) | * |
dc.date.modifydate | 20231116122046 | * |