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dc.contributor.author홍영미*
dc.date.accessioned2016-08-29T11:08:23Z-
dc.date.available2016-08-29T11:08:23Z-
dc.date.issued2009*
dc.identifier.issn0271-9142*
dc.identifier.otherOAK-5379*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/231894-
dc.description.abstractBackground: Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children. Methods: The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method. Results: The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism. Conclusions: Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm. © 2008 Springer Science+Business Media, LLC.*
dc.languageEnglish*
dc.titleThe CCR5 (-2135C/T) polymorphism may be associated with the development of kawasaki disease in Korean children*
dc.typeArticle*
dc.relation.issue1*
dc.relation.volume29*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage22*
dc.relation.lastpage28*
dc.relation.journaltitleJournal of Clinical Immunology*
dc.identifier.doi10.1007/s10875-008-9218-z*
dc.identifier.wosidWOS:000262987100003*
dc.identifier.scopusid2-s2.0-59449086241*
dc.author.googleJhang W.K.*
dc.author.googleKang M.-J.*
dc.author.googleJin H.-S.*
dc.author.googleYu J.*
dc.author.googleKim B.-J.*
dc.author.googleKim B.S.*
dc.author.googleLee J.-K.*
dc.author.googleSeo E.-J.*
dc.author.googleYoo H.-W.*
dc.author.googlePark I.S.*
dc.author.googleHong Y.M.*
dc.author.googleHong S.-J.*
dc.contributor.scopusid홍영미(35210025100;57327441600;55841904000;56063366100)*
dc.date.modifydate20231116122046*
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의과대학 > 의학과 > Journal papers
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