Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성순희 | * |
dc.contributor.author | 문병인 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 임우성 | * |
dc.contributor.author | 박성희 | * |
dc.contributor.author | 박상희 | * |
dc.date.accessioned | 2016-08-29T12:08:04Z | - |
dc.date.available | 2016-08-29T12:08:04Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0046-8177 | * |
dc.identifier.issn | 1532-8392 | * |
dc.identifier.other | OAK-19028 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231726 | - |
dc.description.abstract | GATA-binding protein 3 (GATA3) is a diagnostically useful immunohistochemical marker of breast cancer. Because of its strong association with estrogen receptor expression, GATA3 has markedly reduced sensitivity in triple-negative breast cancer (TNBC). We constructed a tissue microarray using a large series of TNBCs and evaluated GATA3 expression by TNBC subtype as defined by surrogate immunohistochemical markers. A total of 205 TNBCs were classified into cancers of the molecular apocrine type (n = 23, 11.2%), claudin-low type (n = 21, 10.2%), basal-like type (n = 91, 44.4%), mixed type (n = 62, 30.2%), and null type (n = 8, 3.9%). The GATA3 scores (staining intensity x proportion) were categorized as negative (0), focally positive (1-10), or positive (11-300). GATA3 staining was negative in 153 cancers (74.6%), focally positive in 11 (5.4%), and positive in 41 (20.0%). The rate of focal positivity or positivity for GATA3 was significantly higher in the molecular apocrine type (73.9%, 17/23) than in other types of TNBCs (P=.001). The mean GATA3 score of molecular apocrine type TNBC was significantly higher than that of the other types (P=.001) and differed significantly between androgen receptor (AR) positive and AR-negative TNBCs (P<.001). In conclusion, GATA3 expression was correlated strongly with AR positive, molecular apocrine type TNBCs. Co-expression of AR and GATA3 is a specific feature of molecular apocrine type TNBC, which may serve as a diagnostic aid for cancer of unknown primary. (C) 2016 Published by Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | * |
dc.subject | Triple-negative breast carcinoma | * |
dc.subject | Molecular subtype | * |
dc.subject | GATA3 | * |
dc.subject | Androgen receptor | * |
dc.subject | Immunohistochemistry | * |
dc.title | Expression patterns of GATA3 and the androgen receptor are strongly correlated in patients with triple-negative breast cancer | * |
dc.type | Article | * |
dc.relation.volume | 55 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 190 | * |
dc.relation.lastpage | 195 | * |
dc.relation.journaltitle | HUMAN PATHOLOGY | * |
dc.identifier.doi | 10.1016/j.humpath.2016.04.013 | * |
dc.identifier.wosid | WOS:000381541300025 | * |
dc.identifier.scopusid | 2-s2.0-84978034027 | * |
dc.author.google | Kim, Sewha | * |
dc.author.google | Moon, Byung-In | * |
dc.author.google | Lim, Woosung | * |
dc.author.google | Park, Sanghui | * |
dc.author.google | Cho, Min Sun | * |
dc.author.google | Sung, Sun Hee | * |
dc.contributor.scopusid | 성순희(7202731948;58455037400) | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 임우성(27167744500) | * |
dc.contributor.scopusid | 박성희(8848996000) | * |
dc.contributor.scopusid | 박상희(12041890800) | * |
dc.date.modifydate | 20240220100710 | * |