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dc.contributor.author성순희-
dc.contributor.author문병인-
dc.contributor.author조민선-
dc.contributor.author임우성-
dc.contributor.author박성희-
dc.contributor.author박상희-
dc.date.accessioned2016-08-29T12:08:04Z-
dc.date.available2016-08-29T12:08:04Z-
dc.date.issued2016-
dc.identifier.issn0046-8177-
dc.identifier.issn1532-8392-
dc.identifier.otherOAK-19028-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/231726-
dc.description.abstractGATA-binding protein 3 (GATA3) is a diagnostically useful immunohistochemical marker of breast cancer. Because of its strong association with estrogen receptor expression, GATA3 has markedly reduced sensitivity in triple-negative breast cancer (TNBC). We constructed a tissue microarray using a large series of TNBCs and evaluated GATA3 expression by TNBC subtype as defined by surrogate immunohistochemical markers. A total of 205 TNBCs were classified into cancers of the molecular apocrine type (n = 23, 11.2%), claudin-low type (n = 21, 10.2%), basal-like type (n = 91, 44.4%), mixed type (n = 62, 30.2%), and null type (n = 8, 3.9%). The GATA3 scores (staining intensity x proportion) were categorized as negative (0), focally positive (1-10), or positive (11-300). GATA3 staining was negative in 153 cancers (74.6%), focally positive in 11 (5.4%), and positive in 41 (20.0%). The rate of focal positivity or positivity for GATA3 was significantly higher in the molecular apocrine type (73.9%, 17/23) than in other types of TNBCs (P=.001). The mean GATA3 score of molecular apocrine type TNBC was significantly higher than that of the other types (P=.001) and differed significantly between androgen receptor (AR) positive and AR-negative TNBCs (P<.001). In conclusion, GATA3 expression was correlated strongly with AR positive, molecular apocrine type TNBCs. Co-expression of AR and GATA3 is a specific feature of molecular apocrine type TNBC, which may serve as a diagnostic aid for cancer of unknown primary. (C) 2016 Published by Elsevier Inc.-
dc.languageEnglish-
dc.publisherW B SAUNDERS CO-ELSEVIER INC-
dc.subjectTriple-negative breast carcinoma-
dc.subjectMolecular subtype-
dc.subjectGATA3-
dc.subjectAndrogen receptor-
dc.subjectImmunohistochemistry-
dc.titleExpression patterns of GATA3 and the androgen receptor are strongly correlated in patients with triple-negative breast cancer-
dc.typeArticle-
dc.relation.volume55-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage190-
dc.relation.lastpage195-
dc.relation.journaltitleHUMAN PATHOLOGY-
dc.identifier.doi10.1016/j.humpath.2016.04.013-
dc.identifier.wosidWOS:000381541300025-
dc.identifier.scopusid2-s2.0-84978034027-
dc.author.googleKim, Sewha-
dc.author.googleMoon, Byung-In-
dc.author.googleLim, Woosung-
dc.author.googlePark, Sanghui-
dc.author.googleCho, Min Sun-
dc.author.googleSung, Sun Hee-
dc.contributor.scopusid성순희(7202731948)-
dc.contributor.scopusid문병인(7101878644)-
dc.contributor.scopusid조민선(13205279200)-
dc.contributor.scopusid임우성(27167744500)-
dc.contributor.scopusid박성희(8848996000)-
dc.contributor.scopusid박상희(12041890800)-
dc.date.modifydate20210915163347-
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의과대학 > 의학과 > Journal papers
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