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Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- Title
- Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- Authors
- Yi, Hee Jung; Hong, Kyung Sook; Moon, Nara; Chung, Soon Sup; Lee, Ryung-Ah; Kim, Kwang Ho
- Ewha Authors
- 김광호; 이령아; 정순섭; 홍경숙; 문나라
- SCOPUS Author ID
- 김광호; 이령아; 정순섭; 홍경숙; 문나라
- Issue Date
- 2016
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- ISSN
- 2288-6575
2288-6796
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH vol. 90, no. 3, pp. 179 - 182
- Keywords
- Colorectal neoplasma; 5-Fluorouracil; Hyperammonemia; Metabolic brain diseases
- Publisher
- KOREAN SURGICAL SOCIETY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- 5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
- DOI
- 10.4174/astr.2016.90.3.179
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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