Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | - |
dc.date.accessioned | 2016-08-29T12:08:16Z | - |
dc.date.available | 2016-08-29T12:08:16Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | OAK-18096 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/231226 | - |
dc.description.abstract | HPV oncoproteins are selectively retained and expressed in HPV infected carcinoma cells. The E7 oncoprotein interacts with the tumour suppressor Rb, and leads to the progression of oncogenesis. In a previous study, E7 biomarkers were identified in E7 Tg mice. In this study, in order to investigate whether a genotoxic carcinogen would modulate carcinogenesis in the E7-Tg mice, an anticancer drug, melphalan, was intraperitoneally injected into E7-Tg mice for eight weeks at two-day intervals and then genes and proteins were analysed using Omics approaches and RT-qPCR. RT-qPCR was performed to confirm whether E7 biomarkers would be modulated by melphalan treatment in E7-Tg mice, revealing that up-regulated E7 markers such as cyclin B1, CD166, and actin α1 were down-regulated, whereas expression of down-regulated E7 markers such as vimentin was restored by melphalan treatment. These results suggest that melphalan inhibits carcinogenesis via modulating E7-specific genes and proteins expressed in the lung tissues of E7 Tg mice. | - |
dc.language | English | - |
dc.title | Melphalan modulates the expression of E7-specific biomarkers in E7-Tg mice | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2773 | - |
dc.relation.lastpage | 2783 | - |
dc.relation.journaltitle | Anticancer Research | - |
dc.identifier.scopusid | 2-s2.0-77955784560 | - |
dc.author.google | Kim E.J. | - |
dc.author.google | Kim H. | - |
dc.author.google | Lee S. | - |
dc.author.google | Kang J.W. | - |
dc.author.google | Lee D.H. | - |
dc.author.google | Choi H.S. | - |
dc.author.google | Kim J.M. | - |
dc.author.google | Yang Y. | - |
dc.author.google | Sheen Y.Y. | - |
dc.author.google | Park S.N. | - |
dc.author.google | Yoon D.Y. | - |
dc.contributor.scopusid | 신윤용(6603872711) | - |
dc.date.modifydate | 20230411104830 | - |