Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승철 | * |
dc.contributor.author | 김윤환 | * |
dc.date.accessioned | 2016-08-29T12:08:51Z | - |
dc.date.available | 2016-08-29T12:08:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0962-9351 | * |
dc.identifier.other | OAK-16306 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/230988 | - |
dc.description.abstract | Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl-and acetylsalicylic acid-(ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase-(COX-) 2 in stomach tissues and lipopolysaccharide-(LPS-) treated RAW264.7 cells. According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor-(NF-) B and activator protein-(AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk). Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs. © 2016 Jae Gwang Park et al. | * |
dc.language | English | * |
dc.publisher | Hindawi Publishing Corporation | * |
dc.title | Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid | * |
dc.type | Article | * |
dc.relation.volume | 2016 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Mediators of Inflammation | * |
dc.identifier.doi | 10.1155/2016/1903849 | * |
dc.identifier.wosid | WOS:000368398500001 | * |
dc.identifier.scopusid | 2-s2.0-84955466778 | * |
dc.author.google | Park J.G. | * |
dc.author.google | Kim S.C. | * |
dc.author.google | Kim Y.H. | * |
dc.author.google | Yang W.S. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Hong S. | * |
dc.author.google | Kim K.-H. | * |
dc.author.google | Yoo B.C. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Kim J.-H. | * |
dc.author.google | Cho J.Y. | * |
dc.contributor.scopusid | 김승철(35264000100) | * |
dc.contributor.scopusid | 김윤환(55763947200) | * |
dc.date.modifydate | 20240220115825 | * |