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dc.contributor.author김승철-
dc.contributor.author김윤환-
dc.date.accessioned2016-08-29T12:08:51Z-
dc.date.available2016-08-29T12:08:51Z-
dc.date.issued2016-
dc.identifier.issn0962-9351-
dc.identifier.otherOAK-16306-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/230988-
dc.description.abstractAnthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl-and acetylsalicylic acid-(ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase-(COX-) 2 in stomach tissues and lipopolysaccharide-(LPS-) treated RAW264.7 cells. According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor-(NF-) B and activator protein-(AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk). Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs. © 2016 Jae Gwang Park et al.-
dc.languageEnglish-
dc.publisherHindawi Publishing Corporation-
dc.titleAnti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid-
dc.typeArticle-
dc.relation.volume2016-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleMediators of Inflammation-
dc.identifier.doi10.1155/2016/1903849-
dc.identifier.wosidWOS:000368398500001-
dc.identifier.scopusid2-s2.0-84955466778-
dc.author.googlePark J.G.-
dc.author.googleKim S.C.-
dc.author.googleKim Y.H.-
dc.author.googleYang W.S.-
dc.author.googleKim Y.-
dc.author.googleHong S.-
dc.author.googleKim K.-H.-
dc.author.googleYoo B.C.-
dc.author.googleKim S.H.-
dc.author.googleKim J.-H.-
dc.author.googleCho J.Y.-
dc.contributor.scopusid김승철(35264000100)-
dc.contributor.scopusid김윤환(55763947200)-
dc.date.modifydate20190308081000-


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